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Published online before print March 14, 2007, 10.1183/09031936.00092306
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Eur Respir J 2007; 30:104-109
Copyright ©ERS Journals Ltd 2007

An epidemiological study of pulmonary arterial hypertension

A. J. Peacock1, N. F. Murphy2, J. J. V. McMurray2, L. Caballero1 and S. Stewart3

1 Scottish Pulmonary Vascular Unit, Western Infirmary, and 2 Dept of Cardiology, University of Glasgow, Glasgow, UK. 3 Preventative Cardiology, Baker Heart Research Institute, Melbourne, Australia.

CORRESPONDENCE: A. J. Peacock, Scottish Pulmonary Vascular Unit, Western Infirmary, Glasgow, G61 2SW, UK. Fax: 44 1412116334. E-mail: apeacock{at}udcf.gla.ac.uk

Keywords: Epidemiology, incidence, prevalence, pulmonary hypertension

Received: July 12, 2006
Accepted February 26, 2007

All hospitalisations for pulmonary arterial hypertension (PAH) in the Scottish population were examined to determine the epidemiological features of PAH. These data were compared with expert data from the Scottish Pulmonary Vascular Unit (SPVU).

Using the linked Scottish Morbidity Record scheme, data from all adults aged 16–65 yrs admitted with PAH (idiopathic PAH, pulmonary hypertension associated with congenital heart abnormalities and pulmonary hypertension associated with connective tissue disorders) during the period 1986–2001 were identified. These data were compared with the most recent data in the SPVU database (2005).

Overall, 374 Scottish males and females aged 16–65 yrs were hospitalised with incident PAH during 1986–2001. The annual incidence of PAH was 7.1 cases per million population. On December 31, 2002, there were 165 surviving cases, giving a prevalence of PAH of 52 cases per million population. Data from the SPVU were available for 1997–2006. In 2005, the last year with a complete data set, the incidence of PAH was 7.6 cases per million population and the corresponding prevalence was 26 cases per million population.

Hospitalisation data from the Scottish Morbidity Record scheme gave higher prevalences of pulmonary arterial hypertension than data from the expert centres (Scotland and France). The hospitalisation data may overestimate the true frequency of pulmonary arterial hypertension in the population, but it is also possible that the expert centres underestimate the true frequency.




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