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T-cell co-stimulatory molecules: their role in allergic immune reactions

Dept of Paediatrics, Division of Pneumology and Immunology, Charité Medical University of Berlin, Berlin, Germany.

CORRESPONDENCE: E. Hamelmann, Dept of Paediatrics Division of Pneumology and Immunology, Charité Medical University of Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. Fax: 49 30450566931. E-mail: eckard.hamelmann{at}charite.de

Keywords: Allergic airway inflammation, asthma pathogenesis, co-stimulation, T-cells

Received: July 18, 2006
Accepted January 6, 2007

The development of allergic diseases, such as allergic asthma, depends upon the initiation and maintenance of T-helper cell type-2-skewed allergen-specific immune reactions. Although it is clear that susceptibility to this process is under genetic and environmental control, the fine-tuning and regulation of the type-2 T-helper cell immune response is not yet fully understood. In this second article in the present series, current understanding regarding the involvement of T-cells and antigen-presenting cells is summarised, with emphasis on the interaction between these two types of immune regulatory cells by means of co-stimulatory molecules.