ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Published online before print March 1, 2007, 10.1183/09031936.00028706
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wong, M.
Right arrow Articles by Fujisawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, M.
Right arrow Articles by Fujisawa, T.
Eur Respir J 2007; 29:1182-1186
Copyright ©ERS Journals Ltd 2007

Endobronchial ultrasound: new insight for the diagnosis of sarcoidosis

M. Wong1,2,5, K. Yasufuku1,5, T. Nakajima3, F. J. F. Herth3, Y. Sekine1, K. Shibuya1, T. Iizasa1, K. Hiroshima4, W. K. Lam2 and T. Fujisawa1

Depts 1 of Thoracic Surgery, and 4 Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan. 2 Dept of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China. 3 Dept of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany. 5 Both authors contributed equally to this manuscript and are considered first co-authors.

CORRESPONDENCE: T. Fujisawa, Dept of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Fax: 81 432262172. E-mail: fujisawat{at}faculty.chiba-u.jp

Keywords: Bronchoscopy, hilar lymphadenopathy, mediastinum, sarcoidosis, transbronchial needle aspiration, ultrasound

Received: February 2, 2006
Accepted February 15, 2007

A diagnosis of sarcoidosis should be substantiated by pathological means in order to thoroughly exclude other diseases. The role of real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis has not been reported. The purpose of the present study is to evaluate the diagnostic yield of EBUS-TBNA in demonstrating the pathological features of sarcoidosis.

In total, 65 patients with suspected sarcoidosis, with enlarged hilar or mediastinal lymph nodes on computed tomography, were included in the study. Patients with a suspected or known malignancy or previously established diagnosis of sarcoidosis were excluded. Convex probe endobronchial ultrasonography integrated with a separate working channel was used for EBUS-TBNA. Surgical methods were performed in those in whom no granulomas were detected by EBUS-TBNA. Patients were followed up clinically.

EBUS-TBNA was performed on a total of 77 lymph node stations in 65 patients. A final diagnosis of sarcoidosis was made for 61 (93.8%) of the patients. The remaining four patients were diagnosed as having Wegener's granulomatosis (n = 1) or indefinite (n = 3). In patients with a final diagnosis of sarcoidosis, EBUS-TBNA demonstrated noncaseating epithelioid cell granulomas in 56 (91.8%) of the patients. No complications were reported.

Endobronchial ultrasound-guided transbronchial needle aspiration proved to be a safe procedure with a high yield for the diagnoses of sarcoidosis.




This article has been cited by other articles:


Home page
J. Thorac. Cardiovasc. Surg.Home page
R. Trisolini and M. Patelli
Reply to the Editor.
J. Thorac. Cardiovasc. Surg., June 1, 2009; 137(6): 1579 - 1580.e1.
[Full Text] [PDF]


Home page
Arch Otolaryngol Head Neck SurgHome page
Pathology Quiz Case 2: Diagnosis
Arch Otolaryngol Head Neck Surg, June 1, 2009; 135(6): 619 - 620.
[Full Text] [PDF]


Home page
ChestHome page
H. S. Lee, G. K. Lee, H.-S. Lee, M. S. Kim, J. M. Lee, H. Y. Kim, B.-H. Nam, J. I. Zo, and B. Hwangbo
Real-time Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Mediastinal Staging of Non-Small Cell Lung Cancer: How Many Aspirations Per Target Lymph Node Station?
Chest, August 1, 2008; 134(2): 368 - 374.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
F. J.F. Herth, R. K. Morgan, R. Eberhardt, and A. Ernst
Endobronchial Ultrasound-Guided Miniforceps Biopsy in the Biopsy of Subcarinal Masses in Patients with Low Likelihood of Non-Small Cell Lung Cancer
Ann. Thorac. Surg., June 1, 2008; 85(6): 1874 - 1878.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
R. Trisolini, C. Tinelli, A. Cancellieri, D. Paioli, M. Alifano, M. Boaron, and M. Patelli
Transbronchial needle aspiration in sarcoidosis: Yield and predictors of a positive aspirate.
J. Thorac. Cardiovasc. Surg., April 1, 2008; 135(4): 837 - 842.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
S. Garwood, M. A. Judson, G. Silvestri, R. Hoda, M. Fraig, and P. Doelken
Endobronchial Ultrasound for the Diagnosis of Pulmonary Sarcoidosis
Chest, October 1, 2007; 132(4): 1298 - 1304.
[Abstract] [Full Text] [PDF]


Home page
Eur Respir JHome page
M. P. Kennedy, C. A. Jimenez, R. C. Morice, and G. A. Eapen
Is endobronchial ultrasound additive to routine bronchoscopy in diagnosing sarcoidosis?
Eur. Respir. J., September 1, 2007; 30(3): 601 - 602.
[Full Text] [PDF]


Home page
Eur Respir JHome page
M. Wong and K. Yasufuku
From the authors
Eur. Respir. J., September 1, 2007; 30(3): 602 - 602.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the European Respiratory Society.