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Polymorphisms of interleukin-10 and its receptor and lung function in COPD

¹ The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul’s Hospital, University of British Columbia, Vancouver, BC, and ³ Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada. ² Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

CORRESPONDENCE: A. J. Sandford, UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul’s Hospital, 1081 Burrard Street Vancouver, BC, V6Z 1Y6, Canada. Fax: 1 6048068351. E-mail: asandford{at}mrl.ubc.ca

Keywords: Chronic obstructive pulmonary disease, forced expiratory volume in one second, genetic polymorphism, interleukin-10, interleukin-10 receptor, lung function

Received: January 8, 2007
Accepted February 9, 2007

Interleukin (IL)-10 is a type-2 T-helper cell cytokine with a broad spectrum of anti-inflammatory actions. Inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease. It was hypothesised that single nucleotide polymorphisms (SNPs) of the genes encoding IL-10 (IL10) and the subunit of its receptor (IL10RA) are associated with changes in, or value of, forced expiratory volume in one second (FEV₁) in smoking-induced chronic obstructive pulmonary disease.

In total, eleven SNPs of IL10 and IL10RA were studied in 586 White subjects, selected from continuous smokers followed for 5 yrs in the Lung Health Study, who showed the fastest (n = 280) and slowest (n = 306) decline in FEV₁. These 11 SNPs were also studied in 1,072 participants exhibiting the lowest (n = 538) and highest (n = 534) baseline FEV₁ at the beginning of the Lung Health Study.

No association was found in the primary analyses. Although a subgroup analysis showed that the IL-10 3368A allele was associated with a fast decline in FEV₁, the association did not pass correction for multiple comparisons. No gene–gene interaction of IL10 with IL10RA was found.

There was no association of polymorphisms of the genes encoding interleukin-10 and the subunit of its receptor with the rate of decline in, or value of, forced expiratory volume in one second in smoking-induced chronic obstructive pulmonary disease.

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