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Published online before print March 1, 2007, 10.1183/09031936.00000906
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Eur Respir J 2007; 29:958-964
Copyright ©ERS Journals Ltd 2007

Plasma fatty acids and lipid hydroperoxides increase after antibiotic therapy in cystic fibrosis

I. Durieu1, F. Abbas-Chorfa2, J. Drai3, J. Iwaz2, J-P. Steghens4, M. Puget1, R. Ecochard2 and G. Bellon5

1 Dept of Internal Medicine and Cystic Fibrosis, Adult Centre, and 5 Dept of Paediatrics and Cystic Fibrosis, Paediatric Centre, Université Claude Bernard and Hospices Civils de Lyon, and 3 Dept of General, Metabolic and Molecular Biochemistry, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite Cedex, and 4 Federation of Biochemistry, Université Claude Bernard and Hospices Civils de Lyon, Hôpital Edouard Herriot, and 2 Dept of Biostatistics, Hospices Civils de Lyon, Lyon Cedex, France

CORRESPONDENCE: I. Durieu, Cystic fibrosis, Adult Centre, Dept of Internal Medicine, Centre Hospitalier Lyon-Sud, 69495 Pierre-Bénite Cedex, France. Fax: 33 478863264. E-mail: isabelle.durieu{at}chu-lyon.fr

Keywords: Body mass index, cystic fibrosis, fatty acids, forced expiratory volume, lipid hydroperoxide, vitamins

Received: January 4, 2006
Accepted January 19, 2007

The present authors investigated whether cystic fibrosis is linked to a defect in fatty acids and assessed the impact of the main patients' characteristics on the levels of several fatty acids, mostly during respiratory exacerbation and after antibiotic therapy.

Fatty acid phospholipid and cholesteryl ester levels were measured in stable-state patients and controls. No differences were found concerning either the fractions of palmitic and oleic acids or the cholesteryl esters of {alpha}-linolenic and arachidonic acids. However, phospholipids of {alpha}-linolenic and arachidonic acids, as well as cholesteryl esters and phospholipids of stearic and linoleic acids, were lower in patients than in controls, but fractions of dihomo-{gamma}-linolenic, docosatetraenoic, docosapentaenoic, palmitoleic and eicosatrienoic acids were higher.

Fatty acid levels, oxidative stress markers, nutrients, body mass index and forced expiratory volume in one second (FEV1) were measured in patients before and after antibiotic courses for bronchial exacerbation. After adjustments, palmitic, stearic, {alpha}-linolenic, linoleic, arachidonic, palmitoleic and oleic acids generally decreased during exacerbation but almost all increased after antibiotic courses. Nearly all fractions increased along with FEV1 and a positive relationship linked fatty acids to lipid hydroperoxides.

There was no general drop in fatty acids. Patients' fatty acid profiles depended on the pulmonary function and the inflammation state.






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