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Haemoglobin level and its clinical impact in a cohort of patients with COPD

¹ Bay Pines Veterans Affairs Medical Centre (VAMC), Bay Pines, FL, ² Ortho Biotech Clinical Affairs, LLC, Bridgewater, NJ, and ³ St. Elizabeth's Medical Center, Brighton, MA, USA.

CORRESPONDENCE: C. Cote, Dept of Medicine, Respiratory Disease Section, Bay Pines VAMC, 10,000 Bay Pines Boulevard, Bay Pines FL 33744, USA. Fax: 1 7273989549. E-mail: Claudia.Cote{at}med.va.gov

Keywords: Anaemia, chronic obstructive pulmonary disease, dyspnoea, functional outcomes, haemoglobin, mortality

Received: October 22, 2006
Accepted January 8, 2007

Haemoglobin (Hb) abnormalities in chronic obstructive pulmonary disease (COPD) are not well characterised. The present authors investigated the prevalence and association of abnormal Hb with clinical outcomes.

Analysis of a prospective cohort of stable COPD outpatients (n = 683) in a USA Veterans Administration pulmonary clinic was undertaken. Patients were classified as anaemic (Hb <13 g·dL^–1), polycythemic (Hb 17 g·dL^–1 and 15 g·dL^–1 for males and females, respectively) or normal. Demographic characteristics and physiological/functional outcomes were compared between groups. Regression models adjusting for confounders examined the independent association of anaemia with clinical outcomes.

Anaemia was present in 116 (17%) patients and polycythemia in 40 (6%). While the only values that differed between polycythemic and nonpolycythemic patients were mean body mass index and Hb, anaemic patients showed a significantly higher modified Medical Research Council dyspnoea scale score (2.8 versus 2.6), lower 6-min walk distance (265 versus 325 m) and shorter median survival (49 versus 74 months) than nonanaemic patients. In regression models, anaemia independently predicted dyspnoea and reduced exercise capacity.

Anaemia in chronic obstructive pulmonary disease was an independent risk factor for reduced functional capacity. Polycythemia prevalence was low and had no association with worsened outcomes. Further work is required to evaluate the effect of anaemia correction on outcomes in chronic obstructive pulmonary disease.

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