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Exclusion of active Mycobacterium tuberculosis complex infection with the T-SPOT^TM.TB assay

Depts of ¹ Internal Medicine, ² Pulmonology, and ³ Microbiology and Immunology, Diakonessenhuis, Utrecht, The Netherlands.

CORRESPONDENCE: A. W. J. Bossink, Bosboomstraat 1, 3582 KE Utrecht, The Netherlands. Fax: 31 302566738. E-mail: aikbossink{at}mac.com

Keywords: ELISPOT assay, interferon--releasing assay, nontuberculous mycobacteria, tuberculin skin test, tuberculosis

Received: May 14, 2006
Accepted July 14, 2006

The present brief report describes four cases with mycobacterial infection and negative T-SPOT^TM.TB tests. This test proved to be a useful tool to help rule out the diagnosis of active Mycobacterium tuberculosis infection and could therefore prevent unnecessary or inappropriate therapy.

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