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Published online before print November 1, 2006, 10.1183/09031936.00084006
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Eur Respir J 2007; 29:496-501
Copyright ©ERS Journals Ltd 2007

Exhaled breath condensate pH standardised for CO2 partial pressure

T. Kullmann1, I. Barta1, Z. Lázár1, B. Szili2, E. Barát1, M. Valyon3, M. Kollai2 and I. Horváth1,2

1 Dept of Pathophysiology and, 3 Clinical Laboratory, National Korányi Institute for Tuberculosis and Pulmonology, and 2 Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary.

CORRESPONDENCE: I. Horváth, Dept of Human Physiology and Clinical Experimental Research, Semmelweis University, 1082 Budapest Üllüi u. 78/a Hungary. Fax: 36 13343162. E-mail: kiss.horvath{at}t-online.hu

Keywords: Airway biology, airway inflammation, breath test, exhaled biomarkers, exhaled breath condensate

Received: June 27, 2006
Accepted October 23, 2006

Exhaled breath condensate (EBC) pH is considered to reflect the acid-base balance of the airways. Current pH measurements do not take into account the effect of CO2. The aim of the present study was to determine the effect of condensate CO2 partial pressure on pH and to provide a more precise mode of EBC pH determination.

Condensate pH and CO2 partial pressure were measured in parallel from 12 healthy volunteers and 12 asthmatics using a blood gas analyser in neat, argon de-aerated and CO2-loaded samples. The regression analysis was used to test the relationship between pH and CO2, and to calculate the pH at a CO2 level of 5.33 kPa (physiological alveolar CO2 partial pressure). Reproducibility of different pH readings was compared using the Bland–Altman test.

Condensate CO2 concentration was variable both in neat and argon de-aerated samples. There was a close negative logarithmic relationship between CO2 and pH. Calculation of pH at a CO2 level of 5.33 kPa provided reproducibility approximately six times as good as that of the currently used measurements.

Condensate CO2 partial pressure influences pH measurements. Determination of pH at a standard CO2 level provides the most reproducible condensate pH values to date.




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