|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2007
Pulmonary artery distensibility in pulmonary arterial hypertension: an MRI pilot study
1 Pulmonary Division, Pulmonary Hypertension Unit, Heart Institute, University of São Paulo Medical School, and 2 Fleury Research Institute, São Paulo, Brazil. 3 National Pulmonary Hypertension Reference Centre, Hôpital Antoine Béclère, Paris-Sud University, Clamart, France. 4 Pulmonary and Critical Care Division, University of Washington, Seattle, WA, USA.
CORRESPONDENCE: R. Souza, R. Afonso de Freitas 451 Ap 112, São Paulo, 04006-052, Brazil. Fax: 55 1130697202. E-mail: rgrsz{at}uol.com.br
Keywords: Acute vasodilator response, haemodynamic evaluation, magnetic resonance imaging, pulmonary artery distensibility, pulmonary hypertension
Received: February 4, 2006
Accepted November 15, 2006
Pulmonary arterial hypertension (PAH) is a disease of the small vessels in which there is a substantial increase in pulmonary vascular resistance leading to right ventricle failure and death. Invasive haemodynamic evaluation is mandatory not only for diagnosis confirmation but also to address prognosis and eligibility for the use of calcium-channel blockers through an acute vasodilator challenge. Noninvasive surrogate response markers to the acute vasodilator test have been sought.
In the present study, the relationship between pulmonary artery distensibility, assessed using magnetic resonance imaging (MRI), and response to acute vasodilator tests was investigated. In total, 19 patients diagnosed with idiopathic PAH without any specific treatment were evaluated. Within a 48-h window after pulmonary artery catheterisation, patients underwent cardiac MRI.
Cardiac index, calculated after the determination (invasively and noninvasively) of cardiac output, showed excellent correlation, as did right atrial pressure and right ventricle ejection fraction. Pulmonary artery distensibility was significantly higher in responders. A receiver operating characteristic curve analysis has shown that 10% distensibility was able to differentiate responders from nonresponders with 100% sensitivity and 56% specificity.
The present findings suggest that magnetic resonance imaging and pulmonary artery distensibility may be useful noninvasive tools for the evaluation of patients with pulmonary hypertension.
This article has been cited by other articles:
|
|
 |
|
  L. E. R. McLure and A. J. Peacock Cardiac magnetic resonance imaging for the assessment of the heart and pulmonary circulation in pulmonary hypertension Eur. Respir. J., June 1, 2009; 33(6): 1454 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sanz, M. Kariisa, S. Dellegrottaglie, S. Prat-Gonzalez, M. J. Garcia, V. Fuster, and S. Rajagopalan Evaluation of pulmonary artery stiffness in pulmonary hypertension with cardiac magnetic resonance. J. Am. Coll. Cardiol. Img., March 1, 2009; 2(3): 286 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chemla, V. Castelain, S. Provencher, M. Humbert, G. Simonneau, and P. Herve Evaluation of Various Empirical Formulas for Estimating Mean Pulmonary Artery Pressure by Using Systolic Pulmonary Artery Pressure in Adults Chest, March 1, 2009; 135(3): 760 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-W. Lankhaar, N. Westerhof, T. J.C. Faes, C. Tji-Joong Gan, K. M. Marques, A. Boonstra, F. G. van den Berg, P. E. Postmus, and A. Vonk-Noordegraaf Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension Eur. Heart J., July 1, 2008; 29(13): 1688 - 1695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Souza Assessment of compliance in pulmonary arterial hypertension Eur. Heart J., July 1, 2008; 29(13): 1603 - 1604. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |