HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Roiha, H. L. Articles by Frey, U. Search for Related Content PubMed PubMed Citation Articles by Roiha, H. L. Articles by Frey, U.

Alterations of exhaled nitric oxide in pre-term infants with chronic lung disease

¹ Swiss Paediatric Respiratory Research Group, Depts of Paediatrics, and ² Swiss Paediatric Respiratory Research Group, Social and Preventive Medicine, University of Berne, Berne, Switzerland.

CORRESPONDENCE: U. Frey, Swiss Paediatric Respiratory Research Group, Dept of Paediatrics, University Hospital of Berne, Inselspital CH-3010 Berne, Switzerland. Fax: 41 316329484. E-mail: urs.frey{at}insel.ch

Keywords: Chronic lung disease, infants, lung function, nitric oxide, prematurity

Received: February 2, 2006
Accepted October 10, 2006

Animal models suggest that reduced nitric oxide (NO) synthase activity results in lower values of exhaled NO (eNO) present at birth in those individuals who are going to develop chronic lung disease of infancy (CLDI).

Online tidal eNO was measured in 39 unsedated pre-term infants with CLDI (mean gestational age (GA) 27.3 weeks) in comparison with 23 healthy pre-term (31.6 weeks) and 127 term infants (39.9 weeks) at 44 weeks post-conceptional age, thus after the main inflammatory response. NO output (NO output (V'_NO) = eNOxflow) was calculated to account for tidal- flow-related changes. Sex, maternal atopic disease and environmental factors (smoking, caffeine) were controlled for.

The mean eNO was not different (14.9 ppb in all groups) but V'_NO was lower in CLDI compared with healthy term infants (0.52 versus 0.63 nL·s^-1). Values for healthy pre-term infants were between these two groups (0.58 nL·s^-1). Within all pre-term infants (n = 62), V'_NO was reduced in infants with low GA, high clinical risk index for babies scores and longer duration of oxygen therapy but not associated with post-natal factors, such as ventilation or corticosteroid treatment.

After accounting for flow, the lower nitric oxide output in premature infants with chronic lung disease of infancy is consistent with the hypothesis of nitric oxide metabolism being involved in chronic lung disease of infancy.

This article has been cited by other articles:

				C May, O Williams, A D Milner, J Peacock, G F Rafferty, S Hannam, and A Greenough Relation of exhaled nitric oxide levels to development of bronchopulmonary dysplasia Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2009; 94(3): F205 - F209. [Abstract] [Full Text] [PDF]

				C. Gabriele, R. Asgarali, V. W. Jaddoe, A. Hofman, H. A. Moll, and J. C. de Jongste Smoke exposure, airway symptoms and exhaled nitric oxide in infants: the Generation R study Eur. Respir. J., August 1, 2008; 32(2): 307 - 313. [Abstract] [Full Text] [PDF]