HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Bateman, E. D. Search for Related Content PubMed PubMed Citation Articles by Bateman, E. D.

The correlation between asthma control and health status: the GOAL study

¹ University of Cape Town, Cape Town, South Africa., ² Arnaud de Villeneuve Hospital, Montpellier, France., ³ GlaxoSmithKline R&D, Greenford, and ⁵ Imperial College, London, UK. ⁴ University of Wisconsin Medical School, Madison, WI, USA. ⁶ University of Southern Denmark, Kolding Hospital, Kolding, Denmark.

CORRESPONDENCE: E. D. Bateman, UCT Lung Institute, P.O. Box 34560, Groote Schuur 7937, Cape Town, South Africa. Fax: 27 214066902. E-mail: ebateman{at}uctgsh1.uct.ac.za

Keywords: Asthma, control, fluticasone propionate, health status, quality of life, salmeterol

Received: November 3, 2005
Accepted August 27, 2006

The present study examined the association between guideline-derived asthma control and health-related quality of life, assessed using the Asthma Quality of Life Questionnaire (AQLQ), in patients with uncontrolled asthma whose treatment was directed towards achieving the highest possible level of control.

The present randomised, double-blind, parallel-group study compared the efficacy of fluticasone propionate (FP) and salmeterol/fluticasone propionate combination (SFC) in achieving two composite, guideline-derived measures of control: total control (TC) and well-controlled (WC) asthma. Not achieving these levels was classed as not well-controlled (NWC). Doses were augmented until patients achieved TC or reached the maximum dose. This dose was maintained for the remainder of the study. AQLQ was assessed at baseline and at each clinic visit.

AQLQ scores improved throughout the study, reaching near-maximal levels in patients achieving TC and WC, and 52-week mean scores in the three control groups were statistically significantly different. Clinically meaningful improvements (mean change from baseline) were: TC group (SFC 1.9, FP 1.8), WC (SFC 1.5, FP 1.5) and NWC (SFC 1.0, FP 0.9).

In conclusion, the treatment aimed at controlling asthma improves the health-related quality of life to levels approaching normal. The difference in Asthma Quality of Life Questionnaire scores between total control and well-controlled confirms that patients distinguish even between these high levels of control.

This article has been cited by other articles:

				H. K. Reddel, D. R. Taylor, E. D. Bateman, L.-P. Boulet, H. A. Boushey, W. W. Busse, T. B. Casale, P. Chanez, P. L. Enright, P. G. Gibson, et al. An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations: Standardizing Endpoints for Clinical Asthma Trials and Clinical Practice Am. J. Respir. Crit. Care Med., July 1, 2009; 180(1): 59 - 99. [Abstract] [Full Text] [PDF]

				F. L. Nkoy, B. A. Fassl, T. D. Simon, B. L. Stone, R. Srivastava, P. H. Gesteland, G. M. Fletcher, and C. G. Maloney Quality of Care for Children Hospitalized With Asthma Pediatrics, November 1, 2008; 122(5): 1055 - 1063. [Abstract] [Full Text] [PDF]

				E. D. Bateman, S. S. Hurd, P. J. Barnes, J. Bousquet, J. M. Drazen, M. FitzGerald, P. Gibson, K. Ohta, P. O'Byrne, S. E. Pedersen, et al. Global strategy for asthma management and prevention: GINA executive summary Eur. Respir. J., January 1, 2008; 31(1): 143 - 178. [Abstract] [Full Text] [PDF]