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Inhibitory effects of repeated hyperoxia on breathing in newborn mice

¹ INSERM U676, and ³ AP-HP, Service de Réanimation Pédiatrique, Hôpital Robert-Debré, Paris, ² AP-HP, Hôpital Raymond Poincaré, Service de Physiologie, Garches, ⁴ Faculté de Médecine d'Amiens, Amiens, France.

CORRESPONDENCE: F. Lofaso, Service de Physiologie-Explorations Fonctionnelles, Hôpital Raymond Poincaré, 92380 Garches, France. Fax: 33 47107943. E-mail: f.lofaso{at}rpc.ap-hop-paris.fr

Keywords: Neonate, oxygen, respiration

Received: September 26, 2005
Accepted August 29, 2006

Brief oxygen therapy is commonly used for resuscitation at birth or prevention of hypoxaemia before procedures during the neonatal period. However, O₂ may severely depress breathing, especially when administered repeatedly. The aim of the present study was to test the effects of repeated hyperoxia on breathing control in newborn mice.

A total of 97 Swiss mouse pups were assigned to O₂ or air on post-natal day 0, 1 or 2. Each pup in the O₂ group was subjected to four hyperoxic tests (100% O₂ for 3 min followed by 12 min normoxia), whereas pups in the air group were maintained in normoxia. Breathing variables were measured using flow-through barometric plethysmography.

O₂ significantly decreased minute ventilation as seen in a decrease in respiratory rate. This decrease became significantly larger with repeated exposure and ranged -17– -26% for all ages combined. Furthermore, hyperoxia increased total apnoea duration, as compared with the baseline value.

In newborn mice, repeated hyperoxia increasingly depressed breathing. This finding further supports a need for stringent control of oxygen therapy, most notably repeated oxygen administration in the neonatal period for premature newborn infants and those carried to term.

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