HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 28/6/1236    most recent 09031936.00048506v1 Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Birrell, M. A. Articles by Belvisi, M. G. Search for Related Content PubMed PubMed Citation Articles by Birrell, M. A. Articles by Belvisi, M. G.

Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model

¹ Respiratory Pharmacology, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, London, and ² GlaxoSmithKline, Stevenage, UK.

CORRESPONDENCE: M. G. Belvisi, Respiratory Pharmacology Group, Imperial College London, Faculty of Medicine, National Heart & Lung Institute, Dovehouse Street, London, SW3 6LY, UK. Fax: 44 2073518173. E-mail: m.belvisi{at}imperial.ac.uk

Keywords: Airway, biomarker, exhaled, inflammation, nitric oxide, rats

Received: April 7, 2006
Accepted August 25, 2006

There is a great deal of interest in developing less invasive markers for monitoring airway inflammation and the effect of possible novel anti-inflammatory therapies that may take time to impact on disease pathology. Exhaled nitric oxide (eNO) has been shown to be a reproducible, noninvasive indicator of the inflammatory status of the airway in the clinic.

The aim of the present study was to determine the usefulness of measuring eNO as a marker of the anti-inflammatory impact of glucocorticoid and an inhibitor of B kinase-2 (IKK-2) inhibitor 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1), in a pre-clinical model of airway inflammation. Rats were given vehicle, budesonide or TPCA-1 prior to exposure to lipopolysaccharide, previously shown to induce an increase in eNO and airway neutrophilia/eosinophilia.

Comparison of the effect of the two compounds on inflammatory components demonstrated a significant correlation between the impact on eNO and inflammatory cell burden in the airway.

The current study demonstrates the usefulness of profiling potential disease-modifying therapies on exhaled nitric oxide levels and the way in which an effect on this noninvasive biomarker relates to effects on pathological parameters such as lung cellularity. Information from studies such as the current one would suggest that the measurement of exhaled nitric oxide has potential for monitoring inflammatory status in lung tissue.

This article has been cited by other articles:

				L A M Smit, D Heederik, G Doekes, and I M Wouters Exhaled nitric oxide in endotoxin-exposed adults: effect modification by smoking and atopy Occup. Environ. Med., April 1, 2009; 66(4): 251 - 255. [Abstract] [Full Text] [PDF]