|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2006
Respiratory infections associated with nontuberculous mycobacteria in non-HIV patients
1 CHU, Nancy, 2 CHU, Brest, 3 CHU, Clamart, Paris, and 4 CHU Haut-Lévêque, Bordeaux, France.
CORRESPONDENCE: M. Dailloux, Laboratoire de Bactériologie, Hôpital Brabois, Rue du Morvan, 54500 Vandoeuvre les Nancy, France, Fax: 33 383154376. E-mail: m.dailloux{at}chu-nancy.fr
Keywords: HIV-negative patients, nontuberculous mycobacteria, pulmonary diseases
Received: May 11, 2006
Accepted October 13, 2006
The incidence of nontuberculous mycobacteria (NTM) pulmonary diseases in HIV-negative patients was studied prospectively from January 1, 2001 to December 31, 2003 by 32 sentinel sites distributed throughout France.
In total, 262 patients who yielded NTM isolates from respiratory clinical specimens, met the bacteriological, radiological and clinical criteria established by the American Thoracic Society for NTM respiratory disease. Among the 262 NTM isolates, 234 were slow-growing mycobacteria (125 Mycobacterium avium-intracellulare complex (MAC), 66 M. xenopi, 34 M. kansasii) and 28 were rapidly growing mycobacteria (25 M. abscessus complex). In the Paris area, M. xenopi was the most frequently isolated species, followed by MAC.
Most patients (>50%), except those with M. kansasii, had underlying predisposing factors such as pre-existing pulmonary disease or immune deficiency. Asthenia, weight loss, chronic cough and dyspnoea were the most common clinical symptoms. The classical radiological appearance of NTM infections was indistinguishable from that observed in patients with pulmonary tuberculosis.
In summary, the incidence of nontuberculous mycobacteria pulmonary infections in HIV-negative patients was estimated at 0.74, 0.73 and 0.72 cases per 100,000 inhabitants in 2001, 2002 and 2003, respectively.
This article has been cited by other articles:
|
|
 |
|
  A.-L. Roux, E. Catherinot, F. Ripoll, N. Soismier, E. Macheras, S. Ravilly, G. Bellis, M.-A. Vibet, E. Le Roux, L. Lemonnier, et al. Multicenter Study of Prevalence of Nontuberculous Mycobacteria in Patients with Cystic Fibrosis in France J. Clin. Microbiol., December 1, 2009; 47(12): 4124 - 4128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Sampaio, H. Z. Elloumi, A. Zelazny, L. Ding, M. L. Paulson, A. Sher, A. L. Bafica, Y. R. Shea, and S. M. Holland Mycobacterium abscessus and M. avium Trigger Toll-Like Receptor 2 and Distinct Cytokine Response in Human Cells Am. J. Respir. Cell Mol. Biol., October 1, 2008; 39(4): 431 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Glassroth Pulmonary Disease Due to Nontuberculous Mycobacteria Chest, January 1, 2008; 133(1): 243 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Ryu, E. J. Kim, S-H. Lee, S. Y. Kim, G. Y. Suh, M. P. Chung, H. Kim, O. J. Kwon, and W-J. Koh Impaired expression of Toll-like receptor 2 in nontuberculous mycobacterial lung disease Eur. Respir. J., October 1, 2007; 30(4): 736 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. McGrath and N. Qureshi Mycobacterium chelonei: friend or foe? Eur. Respir. J., August 1, 2007; 30(2): 397 - 397. [Full Text] [PDF]
|
|
|
|
 |
|
 Nontuberculous Mycobacterial Infections in HIV-Negative Patients Journal Watch Infectious Diseases, January 24, 2007; 2007(124): 6 - 6. [Full Text]
|
|
|
|
|
|
N. Schonfeld The mycobacterial mystery Eur. Respir. J., December 1, 2006; 28(6): 1076 - 1078. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |