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1 Depts of Pulmonary Diseases, 3 Physics and Medical Technology, and, 4 Clinical Epidemiology and Biostatistics, Institute for Cardiovascular Research ICaR-VU, VU University Medical Centre Amsterdam, The Netherlands, and 2 Dept of Cardiology, University Hospitals Leicester, NHS Trust, Leicester, UK.
CORRESPONDENCE: A. Vonk-Noordegraaf, Dept of Pulmonary diseases, VU University Medical Centre, De Boelelaan 1117, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Fax: 31 204444328. E-mail: a.vonk{at}vumc.nl
Keywords: Magnetic resonance imaging, N-terminal pro brain natriuretic peptide, pulmonary hypertension, right ventricle
Received: February 2, 2006
Accepted August 14, 2006
The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment.
The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up.
There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r = –0.81).
N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function.
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