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Parental smoking increases exhaled nitric oxide in young children

¹ School of Paediatrics and Child Health, University of Western Australia, ² Dept of Respiratory Medicine, Princess Margaret Hospital for Children, and ³ TVW Telethon Institute for Child Health Research, Perth, Australia.

CORRESPONDENCE: P. J. Franklin, School of Paediatrics and Child Health, University of Western Australia, GPO Box D184, Perth 6840, Western Australia. Fax: 61 893882097. E-mail: peterf{at}sph.uwa.edu.au

Keywords: Children, exhaled nitric oxide, passive smoking

Received: January 17, 2006
Accepted June 9, 2006

The present study investigated the association between reported parental smoking and exhaled nitric oxide fraction (F_eNO) in young children.

In total, 78 children (24 females, mean age 51.3 weeks) were recruited. Fourteen lived with one smoking parent and eight with two smoking parents. F_eNO was measured using the modified single-breath technique.

Mean±SD F_eNO levels were 33.0±18.9, 38.3±15.0 and 48.3±14.7 ppb for children with no, one and two smoking parents, respectively. There was a significant linear trend across the groups and, after controlling for other relevant factors, a significant difference between the groups.

In the present study, exposure to environmental tobacco smoke was associated with increased exhaled nitric oxide fraction in young children. Furthermore, there was evidence of a dose–response relationship between childhood exhaled nitric oxide fraction and the number of smoking parents.

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