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Copyright ©ERS Journals Ltd 2006
Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up
1 Sleep Laboratory, Dept of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, and 2 Sleep Medicine Unit, Dept of Neurorehabilitation, Skaraborg Hospital, Skoevde, Sweden.
CORRESPONDENCE: Y. Peker, Sleep Medicine Unit, Dept of Neurorehabilitation, Skaraborg Hospital, SE-54185 Skoevde, Sweden. Fax: 46 500431897. E-mail: yuksel.peker{at}lungall.gu.se
Keywords: Cardiovascular, coronary artery disease, intervention, sleep apnoea
Received: September 13, 2005
Accepted April 13, 2006
An increased incidence of cardiovascular disease has previously been reported in middle-aged males during a follow-up period of 7 yrs. The aim of the present study was to address the incidence of coronary artery disease (CAD) in a larger sample without any heart disease at baseline.
The population comprised 308 snorers (245 males and 63 females) with a mean±SD age of 49.0±9.9 yrs in 1991. Data were collected via the Swedish Hospital Discharge Register, National Cause of Death Registry, clinical charts and questionnaires.
Over 7 yrs, CAD was observed in 17 (16.2%) of 105 patients with obstructive sleep apnoea (OSA; overnight (6 h) oxygen desaturations
It is concluded that middle-aged sleep apnoeics are at high risk of developing coronary artery disease if they are not treated efficiently, which should be considered in cardiovascular disease prevention models.
30 events) compared with 11 (5.4%) of 203 snorers without OSA. OSA diagnosis at baseline was associated with an increased risk of development of CAD in a multivariate model. In the OSA group, CAD was confirmed in 16 (24.6%) of 65 incompletely treated patients compared with one (3.9%) of 26 efficiently treated subjects. Efficient treatment of OSA reduced this risk.
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