HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Kim, H. J. Articles by Yim, J-J. Search for Related Content PubMed PubMed Citation Articles by Kim, H. J. Articles by Yim, J-J.

Prognostic factors for surgical resection in patients with multidrug-resistant tuberculosis

¹ Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine and Lung Institute, ² Dept of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, and, ³ Dept of Thoracic and Cardiovascular Surgery and Respiratory Center, and ⁴ Dept of Internal Medicine and Respiratory Center, Seoul National University Bundang Hospital, Gyeonggi-Do, Republic of Korea.

CORRESPONDENCE: J-J. Yim, Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea. Fax: 82 220729662. E-mail: yimjj{at}snu.ac.kr

Keywords: Multidrug-resistant, prognosis, surgery, tuberculosis

Received: February 13, 2006
Accepted April 21, 2006

Although surgical lung resection could improve prognosis in some patients with multidrug-resistant tuberculosis (MDR-TB), there are no reports on the optimal candidates for this surgery. The aim of the present study was to elucidate the prognostic factors for surgery in patients with MDR-TB.

Patients who underwent lung resection for the treatment of MDR-TB between March 1993 and December 2004 were included in the present study. Treatment failure was defined as greater than or equal to two of the five cultures recorded in the final 12 months of treatment being positive, any one of the final three cultures being positive, or the patient having died during treatment. The variables that affected treatment outcomes were identified through univariate and multivariate logistic regression analysis.

In total, 79 patients with MDR-TB were included in the present study. The treatment outcomes of 22 (27.8%) patients were classified as failure. A body mass index <18.5 kg·m^-2, primary resistance, resistance to ofloxacin and the presence of a cavitary lesion beyond the range of the surgical resection were associated with treatment failure.

Low body mass index, primary resistance, resistance to ofloxacin and cavitary lesions beyond the range of resection are possible poor prognostic factors for surgical lung resection in multidrug-resistant tuberculosis patients.