ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Published online before print April 26, 2006, 10.1183/09031936.06.00103805
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wiebert, P.
Right arrow Articles by Svartengren, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wiebert, P.
Right arrow Articles by Svartengren, M.
Eur Respir J 2006; 28:286-290
Copyright ©ERS Journals Ltd 2006

Negligible clearance of ultrafine particles retained in healthy and affected human lungs

P. Wiebert1,2, A. Sanchez-Crespo3, J. Seitz6, R. Falk4, K. Philipson5, W. G. Kreyling7, W. Möller7, K. Sommerer6, S. Larsson3 and M. Svartengren1,2

1 Dept of Public Health Sciences, Karolinska Institute, 2 Dept of Occupational and Environmental Health, Stockholm County Council, 3 Dept of Nuclear Medicine, Institution of Oncology-Pathology, Karolinska Hospital, 4 The Swedish Radiation Protection Authority, 5 The Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. 6 Intelligent Aerosol Medicine, InAMed GmbH, and 7 GSF National Research Centre for Environment and Health, Institute for Inhalation Biology, Gauting and Munich, Germany.

CORRESPONDENCE: P. Wiebert, Dept of Occupational and Environmental Health, Norrbacka, Karolinska Hospital, SE-171 76 Stockholm, Sweden. Fax: 46 8334333. E-mail: pernilla.wiebert{at}ki.se

Keywords: Air pollution, circulation, clearance, ultrafine particles

Received: September 5, 2005
Accepted April 13, 2006

Ambient particles are believed to be a specific health hazard, although the underlying mechanisms are not fully understood. There are data in the literature indicating fast and substantial systemic uptake of particles from the lung.

The present authors have developed an improved method to produce ultrafine particles with more stable radiolabelling and defined particle size range. Fifteen subjects inhaled technetium 99m (99mTc)-labelled carbonaceous particles of 100 nm in size. Radioactivity over the lung was followed for 70 h. The clearance of these ultrafine particles from the lungs and specifically translocation to the circulation was tested.

Lung retention for all subjects at 46 h was mean±SD 99±4.6%. Cumulative leaching of 99mTc activity from the particles was 2.6±0.96% at 70 h. The 24-h activity leaching in urine was 1.0±0.55%.

No evidence of a quantitatively important translocation of 100-nm particles to the systemic circulation from the lungs was found. More research is needed to establish if the ~1% cleared activity originates from leached activity or insoluble translocated particles, and whether a few per cent of translocated particles is sufficient to cause harmful effects.




This article has been cited by other articles:


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. W. Card, D. C. Zeldin, J. C. Bonner, and E. R. Nestmann
Pulmonary applications and toxicity of engineered nanoparticles
Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L400 - L411.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
R. L. Rouse, G. Murphy, M. J. Boudreaux, D. B. Paulsen, and A. L. Penn
Soot Nanoparticles Promote Biotransformation, Oxidative Stress, and Inflammation in Murine Lungs
Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 198 - 207.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Muhlfeld, B. Rothen-Rutishauser, F. Blank, D. Vanhecke, M. Ochs, and P. Gehr
Interactions of nanoparticles with pulmonary structures and cellular responses
Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L817 - L829.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
M. Geiser, M. Casaulta, B. Kupferschmid, H. Schulz, M. Semmler-Behnke, and W. Kreyling
The Role of Macrophages in the Clearance of Inhaled Ultrafine Titanium Dioxide Particles
Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 371 - 376.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
J. D. Kaufman
Air Pollution and Mortality: Are We Closer to Understanding the How?
Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 325 - 326.
[Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
J. Petersson, A. Sanchez-Crespo, S. A. Larsson, and M. Mure
Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)
J Appl Physiol, January 1, 2007; 102(1): 468 - 476.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the European Respiratory Society.