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Published online before print March 29, 2006, 10.1183/09031936.06.00114705
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Eur Respir J 2006; 28:89-95
Copyright ©ERS Journals Ltd 2006

Estimation of the bronchodilatory effect of deep inhalation after a free run in children

C. Schweitzer1, L. T. T. Vu1, Y. T. Nguyen1, C. Choné1, B. Demoulin2 and F. Marchal1,2

1 Service d’Explorations Fonctionnelles Pédiatriques, Hôpital d’Enfants, Centre Hospitalier Universitaire de Nancy, and 2 Laboratoire de Physiologie, Faculté de Médecine, Vandoeuvre les Nancy, France.

CORRESPONDENCE: F. Marchal, Laboratoire de Physiologie, Faculté de Médecine, Avenue de la Forêt de Haye, F- 54505 Vandoeuvre les Nancy, France, Fax: 33 383683739. E-mail: f.marchal{at}chu-nancy.fr

Keywords: Childhood asthma, exercise-induced bronchial obstruction, lung function measurements, respiratory impedance

Received: October 3, 2005
Accepted February 23, 2006

The bronchomotor effects of a deep inhalation (DI) may provide relevant information about the mechanisms of exercise-induced airway obstruction in children and may be assessed by respiratory conductance (Grs) measured using the forced oscillation technique. The aims of the present study were to assess the effect of DI on Grs after exercise in relationship to the lung function response to exercise.

Grs at 12 Hz using a head generator and spirometric data were measured in 62 children suspected of asthma before and 5 min after a 6-min free run.

After exercise, Grs was significantly increased by DI in 38 subjects, who also showed larger Grs and forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) responses to exercise than the 24 nonresponders. Stepwise regression indicated significant correlation between the response of Grs to DI and both Grs and FEV1/FVC responses to exercise.

The data are consistent with exercise-induced bronchoconstriction being reversed by deep inhalation.






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Copyright © 2006 by the European Respiratory Society.