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Copyright ©ERS Journals Ltd 2006
Comparison of two commercial interferon-
assays for diagnosing Mycobacterium tuberculosis infection
1 Division of Pulmonary Medicine and Critical Care Medicine, Dept of Internal Medicine, Konkuk University Medical Center, Chungju Hospital, Chungju-si, and 2 Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea.
CORRESPONDENCE: T. S. Shim, Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Asan Medical Center, College of Medicine University of Ulsan, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, South Korea, Fax: 82 230106968. E-mail: shimts{at}amc.seoul.kr
Keywords: Interferon-
, Mycobacterium tuberculosis, tuberculin test, tuberculosis
Received: February 4, 2006
Accepted April 4, 2006
The clinical usefulness of ex vivo interferon-
From July 2004 to June 2005 a prospective comparison study was undertaken at a tertiary referral hospital in South Korea. The results of tuberculin skin tests (TST) and the commercially available QuantiFERON-TB Gold (QFT-G) and T SPOT-TB (SPOT) assays were compared in an intermediate TB-burden country.
Of the 224 participants studied, results from all three tests (TST, QFT-G, and SPOT) were available in 218; 87 with active TB and 131 at a low risk for TB. Using 10 mm as a cut-off for TST, SPOT sensitivity (96.6%) was significantly higher than that seen for TST (66.7%) and QFT-G (70.1%). QFT-G showed superior specificity over TST (91.6 versus 78.6%). Although the specificity of QFT-G was higher than that of SPOT (91.6 versus 84.7%), the difference was not statistically significant.
Whilst some differences were found in the performance of the two commercialised interferon-
assays may largely depend on the assay format and epidemiological status of tuberculosis (TB) in the region studied. assays, they seemed to be superior in their detection of Mycobacterium tuberculosis infection compared with tuberculin skin tests. The most appropriate choice of interferon- assay to use may depend on the clinical setting.
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