|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2006
Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment
1 Serveis de Anàlisis Cliniques, 2 Pneumologia, Hospital Universitario Arnau de Vilanova Lleida, 3 Hospital Txagorritxu, Vitoria-Gasteiz, and 4 Hospital Universitari, Son Dureta, Institute Universitari de Ciencies de la Salut (IUNICS), Fundació Caubet-Cimera, Palma de Mallorca and Servicio de Neumología, Spain.
CORRESPONDENCE: A. Barceló, Servicio de Análisis Clínicos, Hospital, Universitari Son Dureta. C/ Andrea Doria 55, 07014 Palma de Mallorca, Spain. Fax: 34 971175228. E-mail: abarcelo{at}hsd.es
Keywords: Clinical trial, continuous positive airway pressure, oxidative stress
Received: June 10, 2005
Accepted November 25, 2005
The episodes of hypoxia/re-oxygenation associated with the respiratory disturbances observed in patients with obstructive sleep apnoea syndrome (OSAS) may induce the generation of oxygen free radicals. Indeed, several studies suggest that OSAS is associated with oxidative stress. The present study tested the hypothesis that patients with OSAS have an alteration in antioxidant defences.
The plasma levels of total antioxidant status (TAS), glutathione peroxidase (GPX),
Patients with OSAS had lower TAS (1.4±0.16 versus 1.50±0.10 mmol·L–1), vitamin A (64±19 versus 74±17 µg·dL–1) and vitamin E levels (1,525±499 versus 1,774±503 µg·dL–1), and increased values of GGT (42±22 versus 32±16 U·L–1) than controls. There was no difference between groups in GPX, homocysteine, vitamin B12 and folate plasma levels. CPAP treatment normalised the levels of TAS (1.50±0.13 mmol·L–1) and the activity of GGT (30±14 U·L–1) without any influence on vitamins levels.
In conclusion, the results indicate that patients with obstructive sleep apnoea syndrome have a decreased antioxidant capacity that is partially reversed by continuous positive airway pressure treatment.
-glutamyltransferase (GGT), vitamins A, E, B12 and folate, and homocysteine were determined in 47 patients with OSAS and 37 healthy subjects. Of these, 27 patients who used continuous positive airway pressure (CPAP) for >4 h·night–1 were re-examined 12 months later.
This article has been cited by other articles:
|
|
 |
|
  V. Pialoux, P. J. Hanly, G. E. Foster, J. V. Brugniaux, A. E. Beaudin, S. E. Hartmann, M. Pun, C. T. Duggan, and M. J. Poulin Effects of Exposure to Intermittent Hypoxia on Oxidative Stress and Acute Hypoxic Ventilatory Response in Humans Am. J. Respir. Crit. Care Med., November 15, 2009; 180(10): 1002 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Alonso-Fernandez, F Garcia-Rio, M A Arias, A Hernanz, M de la Pena, J Pierola, A Barcelo, E Lopez-Collazo, and A Agusti Effects of CPAP on oxidative stress and nitrate efficiency in sleep apnoea: a randomised trial Thorax, July 1, 2009; 64(7): 581 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lavie and P. Lavie Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link Eur. Respir. J., June 1, 2009; 33(6): 1467 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B G Cosio, A Iglesias, A Rios, A Noguera, E Sala, K Ito, P J Barnes, and A Agusti Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD Thorax, May 1, 2009; 64(5): 424 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Belaidi, M. Joyeux-Faure, C. Ribuot, S. H. Launois, P. Levy, and D. Godin-Ribuot Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. J. Am. Coll. Cardiol., April 14, 2009; 53(15): 1309 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Wang, M.-L. Cheng, H.-C. Yen, B.-S. Lou, and H.-C. Liu Vitamin E Suppresses Enhancement of Factor VIII-Dependent Thrombin Generation by Systemic Hypoxia Stroke, February 1, 2009; 40(2): 656 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Levy, J-L. Pepin, C. Arnaud, R. Tamisier, J-C. Borel, M. Dematteis, D. Godin-Ribuot, and C. Ribuot Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives Eur. Respir. J., October 1, 2008; 32(4): 1082 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M D Cross, N L Mills, M Al-Abri, R Riha, M Vennelle, T W Mackay, D E Newby, and N J Douglas Continuous positive airway pressure improves vascular function in obstructive sleep apnoea/hypopnoea syndrome: a randomised controlled trial Thorax, July 1, 2008; 63(7): 578 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Faure, R. Tamisier, J-P. Baguet, A. Favier, S. Halimi, P. Levy, and J-L. Pepin Impairment of serum albumin antioxidant properties in obstructive sleep apnoea syndrome Eur. Respir. J., May 1, 2008; 31(5): 1046 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Sanders, J. M. Montserrat, R. Farre, and R. J. Givelber Positive Pressure Therapy: A Perspective on Evidence-based Outcomes and Methods of Application Proceedings of the ATS, February 15, 2008; 5(2): 161 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gozal and L. Kheirandish-Gozal Cardiovascular Morbidity in Obstructive Sleep Apnea: Oxidative Stress, Inflammation, and Much More Am. J. Respir. Crit. Care Med., February 15, 2008; 177(4): 369 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Sergueeva, G. Y. Miasnikova, D. J. Okhotin, A. A. Levina, Z. Debebe, T. Ammosova, X. Niu, E. A. Romanova, S. Nekhai, P. M. DiBello, et al. Elevated homocysteine, glutathione and cysteinylglycine concentrations in patients homozygous for the Chuvash polycythemia VHL mutation Haematologica, February 1, 2008; 93(2): 279 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kheirandish-Gozal, O. Sans Capdevila, E. Kheirandish, and D. Gozal Elevated Serum Aminotransferase Levels in Children at Risk for Obstructive Sleep Apnea Chest, January 1, 2008; 133(1): 92 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Le Jemtel and S. Jelic Seek and Treat Obstructive Sleep Apnea in Heart Failure J. Am. Coll. Cardiol., April 17, 2007; 49(15): 1632 - 1633. [Full Text] [PDF]
|
|
|
|
|
|
C. L. Phillips and R. R. Grunstein Obstructive sleep apnoea: time for a radical change? Eur. Respir. J., April 1, 2006; 27(4): 671 - 673. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |