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Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1

¹ Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, ² Dept of Thoracic Medicine, Institute of Medicine, and ³ Section for Medical Genetics and Molecular Medicine, Dept of Clinical Medicine, University of Bergen, Bergen, Norway.

CORRESPONDENCE: J. Brøgger, Dept of Neurology, Haukeland University Hospital, Helse Bergen HF, Jonas Liesv. 65, Bergen N-5021, Norway. E-mail: jan.brogger{at}med.uib.no

Keywords: ß₂-adrenergic receptor, case–control study, chronic obstructive pulmonary disease, genetics, microsomal epoxide hydroxylase, tumour necrosis factor-

Received: May 15, 2005
Accepted December 9, 2005

There is evidence of a hereditary component in chronic obstructive pulmonary disease (COPD). A number of genetic association studies have been performed to find susceptibility genes of COPD.

The current authors performed a case–control, genetic-association study and a meta-analysis of 16 studies, involving seven polymorphisms in three well-studied genes: microsomal epoxide hydroxylase (EPHX1); tumour necrosis factor; and ß₂-adrenoreceptor. A total of 492 Caucasian smokers and former smokers were recruited from hospital databases and population cohort studies.

In the present study, a protective effect of the EPHX1 Tyr113His polymorphism was found (homozygous odds ratio (OR) 0.5). In the meta-analysis, homozygotes for this single nucleotide polymorphism (SNP) also had a pooled OR of 0.5. The same effect has been found in several lung cancer studies. Effects for other candidate SNPs were weak or statistically insignificant, and probable genotyping error was common.

In conclusion, the present data and meta-analysis support a role for microsomal epoxide hydroxylase in the aetiology of chronic obstructive pulmonary disease.

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