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Eur Respir J 2006; 27:644-646
Copyright ©ERS Journals Ltd 2006

Fatal haemoptysis in a case of lymphomatoid granulomatosis treated with rituximab

S. Jaffre1, F. Jardin2, S. Dominique1, E. Duet1, Ph. Hubscher3, A. Genevois4, F. Corne1, S. Bota1, G. Nouvet1 and L. Thiberville1

1 Clinique pneumologique and, 4 Service de radiologie, CHU Rouen, and 2 Service hématologie, Centre Bequerel, Rouen, and 3 Service de pneumologie, Hopital Jacques Monod, Le Havre, France.

CORRESPONDENCE: S. Jaffré, Service de Pneumologie, Hôpital Guillaume et René Laennec, Boulevard Jacques Monod, 44093 Nantes Cedex 1, France. Fax: 33 240165241. E-mail: sandrine.jaffre{at}chu-nantes.fr

Keywords: Haemoptysis, lymphomatoid granulomatosis, rituximab

Received: July 21, 2004
Accepted August 15, 2005

Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin. This report describes the case of a 33-yr-old female with an aggressive form of lymphoid granulomatosis treated with an anti-CD20 antibody. Dramatic radiological improvement was seen at the fourth week. However, the patient died at home 1 month after the last rituximab administration from a massive haemoptysis.




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