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1 Dipartimento di Medicina Clinica, University La Sapienza, and 2 Istituto Superiore di Sanita', Rome, and 3 Fondazione Maugeri, Tradate, Varese, and 4 Dept of Experimental Medicine, and 5 Institute of Medicine and Pneumology, University of Palermo, and 6 IBIM-CNR, Palermo, Italy.
CORRESPONDENCE: P. Palange, Dipartimento di Medicina Clinica, University La Sapienza, Viale Università 37, Rome, 00185 Italy. Fax: 39 064940421. E-mail: paolo.palange{at}uniroma1.it
Keywords: CD34+ cells, chronic obstructive pulmonary disease, exercise, growth factors, hypoxia
Received: October 22, 2004
Accepted October 15, 2005
Circulating CD34+ cells are haemopoietic progenitors that may play a role in tissue repair. No data are available on circulating progenitors in chronic obstructive pulmonary disease (COPD).
Circulating CD34+ cells were studied in 18 patients with moderate-to-severe COPD (age: mean±SD 68±8 yrs; forced expiratory volume in one second: 48±12% predicted) and 12 controls, at rest and after endurance exercise. Plasma concentrations of haematopoietic growth factors (FMS-like tyrosine kinase 3 (Flt3) ligand, kit ligand), markers of hypoxia (vascular endothelial growth factor (VEGF)) and stimulators of angiogenesis (VEGF, hepatocyte growth factor (HGF)) and markers of systemic inflammation (tumour necrosis factor (TNF)-
Compared with the controls, the COPD patients showed a three-fold reduction in CD34+ cell counts (3.3±2.5 versus 10.3±4.2 cells·µL–1), and a 50% decrease in AC133+ cells. In the COPD patients, progenitor-derived haemopoietic and endothelial cell colonies were reduced by 30–50%. However, four COPD patients showed progenitor counts in the normal range associated with lower TNF-
In conclusion, circulating CD34+ cells and endothelial progenitors were decreased in chronic obstructive pulmonary disease patients and could be correlated with disease severity.
, interleukin (IL)-6, IL-8) were measured. levels. In the entire sample, CD34+ cell counts correlated with exercise capacity and severity of airflow obstruction. After endurance exercise, progenitor counts were unchanged, while plasma Flt3 ligand and VEGF only increased in the COPD patients. Plasma HGF levels were higher in the COPD patients compared with the controls and correlated inversely with the number of progenitor-derived colonies.
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