|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2006
Obstructive and restrictive spirometric patterns: fixed cut-offs for FEV1/FEV6 and FEV6
1 Dept of General Practice and, 2 Respiratory Division, Academic Hospital, University of Brussels, Brussels, Belgium.
CORRESPONDENCE: J. Vandevoorde, University of Brussels (Vrije Universiteit Brussel), Dept of General Practice, Laarbeeklaan 103, B-1090 Brussels, Belgium. Fax: 32 52373311. E-mail: Jan.Vandevoorde{at}vub.ac.be
Keywords: Chronic obstructive pulmonary disease, forced expiratory volume in six seconds, pulmonary function testing, spirometry
Received: March 25, 2005
Accepted September 8, 2005
The purpose of this study was to determine fixed cut-off points for forced expiratory volume in one second (FEV1)/FEV6 and FEV6 as an alternative for FEV1/forced vital capacity (FVC) and FVC in the detection of obstructive and restrictive spirometric patterns, respectively.
For the study, a total of 11,676 spirometric examinations, which took place on Caucasian subjects aged between 20–80 yrs, were analysed. Receiver–operator characteristic curves were used to determine the FEV1/FEV6 ratio and FEV6 value that corresponded to the optimal combination of sensitivity and specificity, compared with the commonly used fixed cut-off term for FEV1/FVC and FVC.
The data from the current study indicate that FEV1/ FEV6 <73% and FEV6 <82% predicted can be used as a valid alternative for the FEV1/FVC <70% and FVC <80% pred cut-off points for the detection of obstruction and restriction, respectively. The statistical analysis demonstrated very good, overall, agreement between the two categorisation schemes. For the spirometric diagnosis of airway obstruction (prevalence of 45.9%), FEV1/FEV6 sensitivity and specificity were 94.4 and 93.3%, respectively; the positive and negative predictive values were 92.2 and 95.2%, respectively. For the spirometric detection of a restrictive pattern (prevalence of 14.9%), FEV6 sensitivity and specificity were 95.9 and 98.6%, respectively; the positive and negative predictive values were 92.2 and 99.3%, respectively.
This study demonstrates that forced expiratory volume in one second/forced expiratory volume in six seconds <73% and forced expiratory volume in six seconds <82% predicted, can be used as valid alternatives to forced expiratory volume in one second/forced vital capacity <70% and forced vital capacity <80% predicted, as fixed cut-off terms for the detection of an obstructive or restrictive spirometric pattern in adults.
This article has been cited by other articles:
|
|
 |
|
  J.-y. Jing, T.-c. Huang, W. Cui, F. Xu, and H.-h. Shen Should FEV1/FEV6 Replace FEV1/FVC Ratio To Detect Airway Obstruction?: A Metaanalysis Chest, April 1, 2009; 135(4): 991 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Capderou, M. Berkani, M.-H. Becquemin, and M. Zelter A Method to Derive Lower Limit of Normal for the FEV1/Forced Expiratory Volume at 6 s of Exhalation Ratio From FEV1/FVC Data Chest, February 1, 2009; 135(2): 408 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al. Outcomes for COPD pharmacological trials: from lung function to biomarkers Eur. Respir. J., February 1, 2008; 31(2): 416 - 469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vandevoorde, S. Verbanck, D. Schuermans, L. Broekaert, D. Devroey, J. Kartounian, and W. Vincken Forced vital capacity and forced expiratory volume in six seconds as predictors of reduced total lung capacity Eur. Respir. J., February 1, 2008; 31(2): 391 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Bellia, C Sorino, F Catalano, G Augugliaro, N Scichilone, R Pistelli, C Pedone, and R Antonelli-Incalzi Validation of FEV6 in the elderly: correlates of performance and repeatability Thorax, January 1, 2008; 63(1): 60 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kiviranta and T. Haahtela Caucasian race and lung function: time to revisit the racial groups used in reference values Eur. Respir. J., December 1, 2006; 28(6): 1280 - 1280. [Full Text] [PDF]
|
|
|
|
|
|
J. Vandevoorde and M. Swanney Is forced expiratory volume in six seconds a valid alternative to forced vital capacity? Eur. Respir. J., December 1, 2006; 28(6): 1288 - 1289. [Full Text] [PDF]
|
|
|
|
|
|
R. L. Jensen, R. O. Crapo, P. Enright, and Others From the Family Heart Study A Statistical Rationale for the Use of Forced Expired Volume in 6 s Chest, December 1, 2006; 130(6): 1650 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Laszlo Standardisation of lung function testing: helpful guidance from the ATS/ERS Task Force Thorax, September 1, 2006; 61(9): 744 - 746. [Full Text] [PDF]
|
|
|
|
|
|
J. E. Hansen, X-G. Sun, and K. Wasserman Should forced expiratory volume in six seconds replace forced vital capacity to detect airway obstruction? Eur. Respir. J., June 1, 2006; 27(6): 1244 - 1250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. F. Pedersen FEV6: a shortcut in spirometry? Eur. Respir. J., February 1, 2006; 27(2): 245 - 247. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |