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Exhaled nitric oxide is not reduced in infants with cystic fibrosis

¹ School of Paediatrics and Child Health, University of Western Australia, ² Dept of Respiratory Medicine, Princess Margaret Hospital for Children, and ³ TVW Telethon Institute for Child Health Research, Perth, Australia.

CORRESPONDENCE: P. J. Franklin, School of Paediatrics and Child Health, University of Western Australia, GPO Box D184, Perth, 6480, Western Australia. Fax: 61 893882097. E-mail: peterf{at}ichr.uwa.edu.au

Keywords: Airway inflammation, cystic fibrosis, exhaled nitric oxide, infants

Received: June 16, 2005
Accepted September 17, 2005

Fractional exhaled nitric oxide (F_eNO) has been reported to be reduced in cystic fibrosis (CF) patients. However, data from young children are conflicting and it is not clear whether this is a primary feature of the disease or a secondary response. The present study compared F_eNO between CF and healthy infants using a validated single-breath technique.

A total of 23 healthy infants (11 females; mean age 40.1 weeks) and 18 infants with CF (nine females; 64.9 weeks) underwent tests of lung function and F_eNO. Bronchoalveolar lavage (BAL) was collected from all CF infants 2–5 days after lung function testing.

There was no significant difference in F_eNO between the CF and healthy infants (geometric mean: 23.1 parts per billion (ppb) and 17.0 ppb, respectively). There was an inverse relationship between age and F_eNO in the CF patients, but not in the healthy group. Within the CF group, there was no association between F_eNO and any marker of airway inflammation measured in the BAL.

Exhaled nitric oxide is not reduced in cystic fibrosis infants, but does decrease with age. The current data indicate that F_eNO is not a good marker of airway inflammation in cystic fibrosis.

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