ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Georas, S. N.
Right arrow Articles by Casolaro, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Georas, S. N.
Right arrow Articles by Casolaro, V.
Eur Respir J 2005; 26:1119-1137
Copyright ©ERS Journals Ltd 2005

T-helper cell type-2 regulation in allergic disease

S. N. Georas, J. Guo, U. De Fanis and V. Casolaro

Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA

CORRESPONDENCE: S. N. Georas, Johns Hopkins Asthma and Allergy Center, Rm. 4B.41 JHAAC 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA. Fax: 1 4105502612. E-mail: sgeoras{at}jhmi.edu

Keywords: Asthma mechanisms, dendritic cells, gene regulation, lymphocyte subsets

Received: January 14, 2005
Accepted March 21, 2005

Substantial experimental evidence now supports the notion that allergic diseases are characterised by a skewing of the immune system towards a T-helper cell type-2 (Th2) phenotype.

Studies using both human and mouse model systems have provided key evidence for the role that Th2 cytokines play in driving many of the hallmarks of allergic inflammation. Furthermore, the signalling pathways by which Th2 cytokines exert their effects on airway target cells are rapidly being elucidated, and antagonists of the Th2 pathway are under active development.

In this review, the current knowledge of the role of T-helper cell type-2 cells in asthma is summarised, focusing on how and where T-helper cell type-2 cells differentiate from naïve precursors. The signalling molecules and transcription factors involved in T-helper cell type-2 differentiation will be reviewed in detail, in an attempt to translate studies using genetically modified mice into meaningful insights about asthma and other allergic diseases.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
R. P. Vieira, R. C. Claudino, A. C. S. Duarte, A. B. G. Santos, A. Perini, H. C. C. Faria Neto, T. Mauad, M. A. Martins, M. Dolhnikoff, and C. R. F. Carvalho
Aerobic Exercise Decreases Chronic Allergic Lung Inflammation and Airway Remodeling in Mice
Am. J. Respir. Crit. Care Med., November 1, 2007; 176(9): 871 - 877.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
U. De Fanis, F. Mori, R. J. Kurnat, W. K. Lee, M. Bova, N. F. Adkinson, and V. Casolaro
GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells
Blood, May 15, 2007; 109(10): 4343 - 4350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Lang, C. Murgia, M. Leong, L.-W. Tan, G. Perozzi, D. Knight, R. Ruffin, and P. Zalewski
Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation
Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L577 - L584.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
N. N. Hansel and G. B. Diette
Gene Expression Profiling in Human Asthma
Proceedings of the ATS, January 1, 2007; 4(1): 32 - 36.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the European Respiratory Society.