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Sentinel-site surveillance of Mycobacterium avium complex pulmonary disease

¹ Hôpital Haut-Lévêque, ² Hôpital Brabois, ³ Hôpital CHU, ⁴ Institut Pasteur, and ⁵ Hôpital Pitie-Salpetriere, Paris, France.

CORRESPONDENCE: J. Maugein, Laboratoire de Bactériologie, Hôpital Haut Lévêque, Avenue Magellan, 33604 Pessac, Bordeaux, France. Fax: 33 557656867. E-mail: jeanne.maugein{at}chu-bordeaux.fr

Keywords: HIV-negative patients, Mycobacterium avium complex, pulmonary disease

Received: December 28, 2004
Accepted August 8, 2005

The incidence of Mycobacterium avium complex (MAC) pulmonary disease in HIV-negative patients was studied prospectively from January 1, 2000 to December 31, 2002 through 32 sentinel sites distributed all over France.

Among the 275 patients who yielded MAC isolates from respiratory clinical specimens, 101 (36.7%) met the bacteriological, radiographical and clinical criteria established by the American Thoracic Society for nontuberculous mycobacterial respiratory disease. Of these 101 patients, 81 had underlying lung disease, mainly previous tuberculosis, bronchectasis or chronic obstructive pulmonary disease.

Among the 20 patients with no underlying lung disease, 12 had a predisposing factor such as leukaemia or immunosuppressive treatment and eight had no predisposing factor. All patients with MAC respiratory disease had clinical symptoms, commonly cough and fatigue, and 52 (51.5%) were sputum smear positive for acid-fast bacillus.

The ratio of patients with Mycobacterium avium complex pulmonary disease to patients with pulmonary tuberculosis in France was estimated to be 3% and the incidence of Mycobacterium avium complex pulmonary disease in France was 0.2 per 100,000 inhabitants.

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