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Eur Respir J 2005; 26:858-863
Copyright ©ERS Journals Ltd 2005

Goal-oriented treatment and combination therapy for pulmonary arterial hypertension

M. M. Hoeper, I. Markevych, E. Spiekerkoetter, T. Welte and J. Niedermeyer

Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany

CORRESPONDENCE: M. M. Hoeper, Hannover Medical School, Dept of Respiratory Medicine, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Fax: 49 5115328536. E-mail: hoeper.marius{at}mh-hannover.de

Keywords: Endothelin receptor antagonists, hypertension, prostaglandins, pulmonary, sildenafil

Received: June 27, 2005
Accepted July 26, 2005

Combination therapy may improve outcome in patients with severe pulmonary arterial hypertension (PAH).

PAH patients were treated according to a goal-oriented therapeutic strategy. Patients who did not reach the treatment goals with monotherapy received combination treatment according to a predefined strategy, including bosentan, sildenafil and inhaled iloprost. Intravenous iloprost and lung transplantation were reserved for treatment failures. End points were overall survival, transplantation-free survival, and survival free from transplantation and intravenous prostanoid treatment.

Between January 2002 and December 2004, 123 consecutive patients with PAH were treated according to the novel approach. Survival at 1, 2 and 3 yrs was 93.0, 83.1 and 79.9%, respectively, which was significantly better than the survival of a historical control group, as well as the expected survival. Compared to the historical control group, the use of combination treatment also significantly improved the combined end point of death, lung transplantation and need for intravenous iloprost treatment.

In conclusion, a therapeutic approach utilising combinations of bosentan, sildenafil and inhaled iloprost in conjunction with a goal-oriented treatment strategy provides acceptable long-term results in patients with severe pulmonary arterial hypertension, and reduces the need for intravenous prostaglandin treatment and lung transplantation.




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