|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2005
Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers
1 Dept of Pathology, and 2 Dept of Pulmonology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
CORRESPONDENCE: W. Timens, University Medical Centre Groningen, Dept of Pathology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. Fax: 31 0503632510. E-mail: w.timens{at}path.umcg.nl
Keywords: Airway inflammation, asymptomatic smokers, bronchial biopsies, chronic obstructive pulmonary disease, induced sputum, smoking cessation
Received: September 20, 2004
Accepted July 1, 2005
Smoking cessation is the only treatment in patients with chronic obstructive pulmonary disease (COPD) effective in slowing down disease progression. Its effect on airway inflammation in COPD is unknown, although cross-sectional studies suggest ongoing inflammation in ex-smokers.
In order to elucidate the effect of smoking cessation on airway inflammation, 28 smokers with COPD (mean age: 55 yrs; forced expiratory volume in one second: 71% predicted) and 25 asymptomatic smokers with normal lung function (aged 50 yrs) were included in a 1-yr smoking cessation programme. Effects of smoking cessation on airway inflammation were investigated in bronchial biopsies (baseline, 12 months) and sputum samples (baseline, 2, 6 and 12 months).
In the 12 candidates with COPD who successfully ceased smoking, airway inflammation persisted in bronchial biopsies, while the number of sputum neutrophils, lymphocytes, interleukin (IL)-8 and eosinophilic-cationic-protein levels significantly increased at 12 months. In the 16 asymptomatic smokers who successfully quitted, inflammation significantly reduced (i.e. number of sputum macrophages, percentage of eosinophils and IL-8 levels) or did not change.
The current authors suggest that the observed persistent airway inflammation in patients with chronic obstructive pulmonary disease is related to repair of tissue damage in the airways. It remains to be elucidated whether this reflects a beneficial or detrimental effect.
This article has been cited by other articles:
|
|
 |
|
  W. MacNee and R. M. Tuder New Paradigms in the Pathogenesis of Chronic Obstructive Pulmonary Disease I Proceedings of the ATS, September 15, 2009; 6(6): 527 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Brusselle, T. Demoor, K. R. Bracke, C-A. Brandsma, and W. Timens Lymphoid follicles in (very) severe COPD: beneficial or harmful? Eur. Respir. J., July 1, 2009; 34(1): 219 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Hansel, L. Gao, N. M. Rafaels, R. A. Mathias, E. R. Neptune, C. Tankersley, A. V. Grant, J. Connett, T. H. Beaty, R. A. Wise, et al. Leptin receptor polymorphisms and lung function decline in COPD Eur. Respir. J., July 1, 2009; 34(1): 103 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Sussan, T. Rangasamy, D. J. Blake, D. Malhotra, H. El-Haddad, D. Bedja, M. S. Yates, P. Kombairaju, M. Yamamoto, K. T. Liby, et al. From the Cover: Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice PNAS, January 6, 2009; 106(1): 250 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. I. Rennard and J. Vestbo Natural Histories of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, December 15, 2008; 5(9): 878 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. I. Rennard Lessons from Multidisciplinary Cross-Fertilization: Chronic Obstructive Pulmonary Disease, Lung Cancer, and Heart Disease Proceedings of the ATS, December 1, 2008; 5(8): 865 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Barcelo, J. Pons, J. M. Ferrer, J. Sauleda, A. Fuster, and A. G. N. Agusti Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking Eur. Respir. J., March 1, 2008; 31(3): 555 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hoshino, T. Nakamura, A. Sato, M. Mishima, J. Yodoi, and H. Nakamura Neurotropin Demonstrates Cytoprotective Effects in Lung Cells through the Induction of Thioredoxin-1 Am. J. Respir. Cell Mol. Biol., October 1, 2007; 37(4): 438 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. I. Rennard Inflammation in COPD: a link to systemic comorbidities Eur. Respir. Rev., September 1, 2007; 16(105): 91 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gamble, D. C. Grootendorst, K. Hattotuwa, T. O'Shaughnessy, F. S. F. Ram, Y. Qiu, J. Zhu, A. M. Vignola, C. Kroegel, F. Morell, et al. Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis Eur. Respir. J., September 1, 2007; 30(3): 467 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Parimon, J. W. Chien, C. L. Bryson, M. B. McDonell, E. M. Udris, and D. H. Au Inhaled Corticosteroids and Risk of Lung Cancer among Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 712 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Hylkema, P. J. Sterk, W. I. de Boer, and D. S. Postma Tobacco use in relation to COPD and asthma Eur. Respir. J., March 1, 2007; 29(3): 438 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. J. Vernooy, G. M. Moller, R. J. van Suylen, M. P. van Spijk, R. H. E. Cloots, P. H. Hoet, H. J. Pennings, and E. F. M. Wouters Increased Granzyme A Expression in Type II Pneumocytes of Patients with Severe Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 1, 2007; 175(5): 464 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Verbanck, D. Schuermans, M. Paiva, M. Meysman, and W. Vincken Small Airway Function Improvement after Smoking Cessation in Smokers without Airway Obstruction Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 853 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Stockley Neutrophilic inflammation: "Don't you go to pieces on me!". Eur. Respir. J., August 1, 2006; 28(2): 257 - 258. [Full Text] [PDF]
|
|
|
|
|
|
R. M. Tuder, T. Yoshida, W. Arap, R. Pasqualini, and I. Petrache State of the Art. Cellular and Molecular Mechanisms of Alveolar Destruction in Emphysema: An Evolutionary Perspective Proceedings of the ATS, August 1, 2006; 3(6): 503 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chaudhuri, E. Livingston, A. D. McMahon, J. Lafferty, I. Fraser, M. Spears, C. P. McSharry, and N. C. Thomson Effects of Smoking Cessation on Lung Function and Airway Inflammation in Smokers with Asthma Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 127 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J F Donohue Ageing, smoking and oxidative stress. Thorax, June 1, 2006; 61(6): 461 - 462. [Full Text] [PDF]
|
|
|
|
|
|
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe Update in chronic obstructive pulmonary disease 2005. Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065. [Full Text] [PDF]
|
|
|
|
|
|
S. I. Rennard Chronic Obstructive Pulmonary Disease: Linking Outcomes and Pathobiology of Disease Modification Proceedings of the ATS, May 1, 2006; 3(3): 276 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Polosa Smoking cessation: a critical investigative tool in COPD. Eur. Respir. J., April 1, 2006; 27(4): 860 - 861. [Full Text] [PDF]
|
|
|
|
|
|
B. W. M. Willemse, N. H. T. ten Hacken, D. S. Postma, and W. Timens From the authors Eur. Respir. J., April 1, 2006; 27(4): 861 - 862. [Full Text] [PDF]
|
|
|
|
|
|
P. W. Ind COPD disease progression and airway inflammation: uncoupled by smoking cessation Eur. Respir. J., November 1, 2005; 26(5): 764 - 766. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |