HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Struben, V. M. D. Articles by de Jongste, J. C. Search for Related Content PubMed PubMed Citation Articles by Struben, V. M. D. Articles by de Jongste, J. C.

Nasal NO: normal values in children age 6 through to 17 years

¹ Dept of Otolaryngology, and ³ Dept of Paediatric Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands. ² Dept of Paediatrics, School of Medicine DPMSC, University of Udine, Italy.

CORRESPONDENCE: J. C. de Jongste, Erasmus medical centre/Sophia Children's Hospital, Dept Paediatric Respiratory Medicine, Dr. Molewaterplein 60, 3015 GD Rotterdam, The Netherlands. Fax: 31 104636811. E-mail: j.c.dejongste@erasmusmc.nl

Keywords: Children, nasal nitric oxide, normal values

Received: February 10, 2005
Accepted May 4, 2005

The present study is an assessment of normal values of nasal nitric oxide (nNO) in healthy children.

Healthy children aged between 6–17 yrs were recruited from three schools in Rotterdam (The Netherlands). Breath was held for 10 s, while air was extracted from one nostril at 700 mL·min^–1. The mean nNO value at the response plateau after 7–10 s was recorded and the average of three measurements was used.

In total, 340 children participated; the male:female ratio was 156:184. Three reliable measurements were available in 85% of the children. The nNO concentrations were distributed normally (mean 449 ppb, SD 115). They were not associated with sex, passive smoking or body mass index. In children aged <12 yrs nNO correlated positively with age, history of adenoidectomy and ambient NO. In children aged 12 yrs ambient NO was the only significant modifier. Prediction rules for nNO values in children were formulated.

In conclusion, the current study presents normal values for nasal nitric oxide in children, which can be used to assess the value of nasal nitric oxide in respiratory illnesses.

This article has been cited by other articles:

				A Bodini, S Rugolotto, U Pradal, G Zanotto, and D Peroni Nasal nitric oxide for early diagnosis of familial primary ciliary dyskinesia Arch. Dis. Child., May 1, 2008; 93(5): 452 - 453. [Full Text] [PDF]