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Dietary intake of flavonoids and asthma in adults

¹ Dept of Public Health Sciences, King's College London, London, ⁴ Dept of Social Medicine, University of Bristol, Bristol, and ⁵ Institute of Human Nutrition, University of Southampton, Southampton, UK. ² Dept of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile. ³ RIKILT, Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands.

CORRESPONDENCE: S. Shaheen, Dept of Public Health Sciences, King's College London, 5th Floor, Capital House, 42 Weston St, London, SE1 3QD, UK. Fax: 44 2078486605. E-mail: seif.shaheen@kcl.ac.uk

Keywords: Antioxidants, apples, asthma, diet, flavonoids

Received: December 13, 2004
Accepted May 30, 2005

Epidemiological studies have suggested that a high consumption of apples may protect against asthma and chronic obstructive pulmonary disease. This effect has been attributed to their high flavonoid content, but few studies have investigated the relationship between flavonoid intake and obstructive lung disease directly.

In a population-based, case-control study of 1,471 adults aged 16–50 yrs in London (UK), the present study examined whether dietary intake of catechins, flavonols and flavones was negatively associated with asthma, asthma severity and chronic sputum production. Asthma was defined by positive responses to a standard screening questionnaire in 1996 and information about usual diet was obtained by a food frequency questionnaire in 1997.

After controlling for potential confounders, dietary intake of these three flavonoid subclasses was not significantly associated with asthma, (odds ratio per quintile (95% confidence interval) = 0.94 (0.86–1.02); 1.00 (0.92–1.09); 0.98 (0.88 –1.08) for flavones, flavonols and total catechins, respectively) nor was it associated with asthma severity, or chronic sputum production.

In conclusion, no evidence was found for a protective effect of three major subclasses of dietary flavonoids on asthma. It is possible that other flavonoids or polyphenols present in apples may explain the protective effect of apples on obstructive lung disease.

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