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Eur Respir J 2005; 26:140-152
Copyright ©ERS Journals Ltd 2005

Computed tomographic imaging of the airways: relationship to structure and function

P. A. de Jong1,2,3, N. L. Müller3, P. D. Paré2 and H. O. Coxson2,3

1 Dept of Paediatric Pulmonology, Erasmus MC-Sophia, Rotterdam, The Netherlands. 2 James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, and 3 Dept of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

CORRESPONDENCE: H. O. Coxson, Dept of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, V5Z 1M9, Canada. Fax: 1 6048754319. E-mail: harvey.coxson@vch.ca

Keywords: Airways, asthma, chronic obstructive pulmonary disease, computed tomography, cystic fibrosis, lung structure and function

Received: January 19, 2005
Accepted March 25, 2005

Alterations in the structure of the airways, collectively termed airway remodelling, contribute to airflow obstruction in a variety of chronic lung diseases. While histology has provided valuable insights into the structure of airway wall remodelling, this technique is invasive and does not allow the longitudinal analysis of airway wall dimensions. Technical advances in computed tomography allow the assessment of airway wall dimensions, and are ideally suited for the noninvasive investigation of the pathogenesis of airway wall remodelling and the evaluation of new therapeutic interventions. The aim of this article is to review the use of computed tomography in the investigation of airway structure and function in health and disease.




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