|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2005
Adenosine level in exhaled breath increases during exercise-induced bronchoconstriction
Depts of 1 Pulmonology, and 2 Pathophysiology, National Korányi Institute for Tuberculosis and Pulmonology, Budapest, Hungary
CORRESPONDENCE: I. Horváth, National Korányi Institute for Tuberculosis and Pulmonology, Dept of Pathophysiology, Budapest, Pihenö u.1. P.O. Box 1, H-1529, Hungary. Fax: 36 12007060. E-mail: hildiko@koranyi.hu
Keywords: Adenosine, airway inflammation, asthma, exercise-induced bronchoconstriction, exhaled breath condensate
Received: September 23, 2004
Accepted December 15, 2004
In asthmatic patients, airway obstruction provoked by exercise challenge is accompanied by an increase in plasma adenosine level. In this study, the current authors investigated if exercise-induced bronchoconstriction was associated with local changes of adenosine concentration in the airways.
Oral exhaled breath condensate (EBC) collection (5-min duration) and forced expiratory volume in one second (FEV1) measurements were performed at rest (baseline) and 4–8 times after treadmill exercise challenge in healthy and asthmatic subjects. Adenosine concentration in EBC was determined by HPLC.
Observations indicated that physical exercise results in bronchoconstriction together with a significant increase of adenosine level in EBC in asthmatic patients (mean±SD maximal fall in FEV1 27±13%; associated increase in adenosine 110±76% as compared to baseline), but not in healthy control subjects. Exercise-induced changes in adenosine concentration correlated significantly with the fall in FEV1 values in asthmatic patients.
In conclusion, the observed increase in adenosine concentration of oral exhaled breath condensate most probably reflects changes in the airways during exercise-induced bronchoconstriction. Due to its known bronchoconstrictor property in asthma, adenosine may contribute to the development of bronchospasm.
This article has been cited by other articles:
|
|
 |
|
  S. V. Novitskiy, S. Ryzhov, R. Zaynagetdinov, A. E. Goldstein, Y. Huang, O. Y. Tikhomirov, M. R. Blackburn, I. Biaggioni, D. P. Carbone, I. Feoktistov, et al. Adenosine receptors in regulation of dendritic cell differentiation and function Blood, September 1, 2008; 112(5): 1822 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Esther Jr, N. E. Alexis, M. L. Clas, E. R. Lazarowski, S. H. Donaldson, C. M. Pedrosa Ribeiro, C. G. Moore, S. D. Davis, and R. C. Boucher Extracellular purines are biomarkers of neutrophilic airway inflammation Eur. Respir. J., May 1, 2008; 31(5): 949 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Brown, G. W. Clarke, C. L. Ledbetter, M. J. Hurle, J. C. Denyer, D. E. Simcock, J. E. Coote, T. J. Savage, R. D. Murdoch, C. P. Page, et al. Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects Eur. Respir. J., February 1, 2008; 31(2): 311 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Horvath From the authors Eur. Respir. J., July 1, 2007; 30(1): 187 - 187. [Full Text] [PDF]
|
|
|
|
 |
|
 X. Hua, C. J. Erikson, K. D. Chason, C. N. Rosebrock, D. A. Deshpande, R. B. Penn, and S. L. Tilley Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L25 - L32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mohsenin, M. D. Burdick, J. G. Molina, M. P. Keane, and M. R. Blackburn Enhanced CXCL1 production and angiogenesis in adenosine-mediated lung disease FASEB J, April 1, 2007; 21(4): 1026 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Horvath, J. Hunt, P. J. Barnes, and On behalf of the ATS/ERS Task Force on Exhaled Bre Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J., September 1, 2005; 26(3): 523 - 548. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |