|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2005
Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease
First Dept of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
CORRESPONDENCE: K. Fujimoto, First Dept of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. Fax: 81 263363722. E-mail: keisaku@hsp.md.shinshu-u.ac.jp
Keywords: Acute exacerbation, airway inflammation, chemoattractant, eosinophils, neutrophils
Received: April 22, 2004
Accepted December 21, 2004
The aim of this study was to clarify the mechanism of increased airway inflammation during an acute exacerbation.
A total of 68 chronic obstructive pulmonary disease patients in a stable phase were enrolled and followed-up for 2–3 yrs. Inflammatory cells were analysed, and interleukin (IL)-8, neutrophil elastase, eotaxin, tryptase and RANTES (regulated on activation, normal T-cell expressed and secreted) were measured in sputum, both in a stable phase and during acute exacerbation.
Out of 68 patients, 30 (unstable group) developed an acute exacerbation and expectorated adequate sputum during exacerbation. Thirty-two patients (stable group) did not develop any exacerbation for 2–3 yrs. The number of neutrophils, lymphocytes and eosinophils, and the levels of IL-8, eosinophil cationic protein (ECP), eotaxin and tryptase in sputum obtained from patients in both groups during the stable phase were significantly higher than those from healthy nonsmokers. There were no significant differences in cell analysis and biomarkers between the two groups, but patients in the unstable group showed more severe airflow limitation. In the unstable group, total cells, lymphocytes, neutrophils and eosinophils, and IL-8, neutrophil elastase, ECP and RANTES levels were significantly increased during an exacerbation from values in a stable phase.
These findings suggest that exacerbation of chronic obstructive pulmonary disease may associate with additional increases in airway inflammation mediated by neutrophils, lymphocytes, eosinophils, interleukin-8 and RANTES.
This article has been cited by other articles:
|
|
 |
|
  J. A. Falk, O. A. Minai, and Z. Mosenifar Inhaled and Systemic Corticosteroids in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, May 1, 2008; 5(4): 506 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sethi, C. Wrona, K. Eschberger, P. Lobbins, X. Cai, and T. F. Murphy Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 1, 2008; 177(5): 491 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sykes, P. Mallia, and S. L. Johnston Diagnosis of Pathogens in Exacerbations of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, December 1, 2007; 4(8): 642 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Martinez Pathogen-directed Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, December 1, 2007; 4(8): 647 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Curtis, C. M. Freeman, and J. C. Hogg The Immunopathogenesis of Chronic Obstructive Pulmonary Disease: Insights from Recent Research Proceedings of the ATS, October 1, 2007; 4(7): 512 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. R. Celli and P. J. Barnes Exacerbations of chronic obstructive pulmonary disease Eur. Respir. J., June 1, 2007; 29(6): 1224 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Bathoorn, J. Liesker, D. Postma, G. Koeter, A. J. M. van Oosterhout, and H. A. M. Kerstjens Safety of Sputum Induction During Exacerbations of COPD Chest, February 1, 2007; 131(2): 432 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G M Turino Emphysema in COPD: consequences and causes. Thorax, December 1, 2006; 61(12): 1031 - 1036. [Full Text] [PDF]
|
|
|
|
|
|
P Boschetto, S Quintavalle, E Zeni, S Leprotti, A Potena, L Ballerin, A Papi, G Palladini, M Luisetti, L Annovazzi, et al. Association between markers of emphysema and more severe chronic obstructive pulmonary disease Thorax, December 1, 2006; 61(12): 1037 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mallia and S. L. Johnston How viral infections cause exacerbation of airway diseases. Chest, October 1, 2006; 130(4): 1203 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Papi, C. M. Bellettato, F. Braccioni, M. Romagnoli, P. Casolari, G. Caramori, L. M. Fabbri, and S. L. Johnston Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1114 - 1121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Papi, F. Luppi, F. Franco, and L. M. Fabbri Pathophysiology of Exacerbations of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, May 1, 2006; 3(3): 245 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R O'Donnell, D Breen, S Wilson, and R Djukanovic Inflammatory cells in the airways in COPD Thorax, May 1, 2006; 61(5): 448 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Sapey and R A Stockley COPD exacerbations {middle dot} 2: Aetiology. Thorax, March 1, 2006; 61(3): 250 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Hurst, W. R. Perera, T. M. A. Wilkinson, G. C. Donaldson, and J. A. Wedzicha Systemic and Upper and Lower Airway Inflammation at Exacerbation of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 71 - 78. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |