| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
National Heart and Lung Institute, Imperial College, London, UK
CORRESPONDENCE: P. J. Barnes, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse St, London SW3 6LY, UK. Fax: 44 2073515675. E-mail: p.j.barnes@imperial.ac.uk
Keywords: Chromatin, histone acetylation, histone acetyltransferase, histone deacetylate, transcription factor
Received: October 13, 2004
Accepted November 30, 2004
ABSTRACT
Inflammatory lung diseases are characterised by increased expression of multiple inflammatory genes that are regulated by proinflammatory transcription factors, such as nuclear factor-
Conversely, gene repression is mediated via histone deacetylases (HDACs) and other corepressors. In asthma, there is an increase in HAT activity and some reduction in HDAC activity, which is restored by corticosteroid therapy. Corticosteroids switch off inflammatory genes in asthma through the inhibition of HAT activity and by the recruitment of HDAC2 to the activated inflammatory gene complex. In chronic obstructive pulmonary disease, there is a reduction in HDAC2 activity and expression, which may account for the amplified inflammation and resistance to the actions of corticosteroids. The reduction in HDAC2 may be secondary to oxidative and nitrative stress as a result of cigarette smoking and severe inflammation, and may also occur in severe asthma, smoking asthmatic patients and cystic fibrosis.
Similar mechanisms may also account for the steroid resistance seen with latent adenovirus infections. The reduction in histone deacetylase activity can be restored by theophylline, which may be able to reverse steroid resistance in chronic obstructive pulmonary disease and other inflammatory diseases.
B. Gene expression is regulated by acetylation of core histones through the action of coactivators, such as CREB-binding protein, with intrinsic histone acetyltransferase (HAT) activity.
This article has been cited by other articles:
|
|
 |
|
  K. F. Chung and I. M. Adcock Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction Eur. Respir. J., June 1, 2008; 31(6): 1334 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sharafkhaneh, N. A. Hanania, and V. Kim Pathogenesis of Emphysema: From the Bench to the Bedside Proceedings of the ATS, May 1, 2008; 5(4): 475 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-W. Lee, C.-C. Lin, S.-F. Luo, H.-C. Lee, I.-T. Lee, W. C. Aird, T.-L. Hwang, and C.-M. Yang Tumor Necrosis Factor-{alpha} Enhances Neutrophil Adhesiveness: Induction of Vascular Cell Adhesion Molecule-1 via Activation of Akt and CaM Kinase II and Modifications of Histone Acetyltransferase and Histone Deacetylase 4 in Human Tracheal Smooth Muscle Cells Mol. Pharmacol., May 1, 2008; 73(5): 1454 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sharafkhaneh, S. Velamuri, V. Badmaev, C. Lan, and N. Hanania Review: The potential role of natural agents in treatment of airway inflammation Therapeutic Advances in Respiratory Disease, December 1, 2007; 1(2): 105 - 120. [Abstract] [PDF]
|
|
|
|
|
|
H. Dombrowsky and S. Uhlig Steroids and histone deacetylase in ventilation-induced gene transcription Eur. Respir. J., November 1, 2007; 30(5): 865 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-b. Li, D. Y. M. Leung, M. J. Strand, and E. Goleva ATF2 impairs glucocorticoid receptor mediated transactivation in human CD8+ T cells Blood, September 1, 2007; 110(5): 1570 - 1577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Cao, P. A. Bromberg, and J. M. Samet COX-2 Expression Induced by Diesel Particles Involves Chromatin Modification and Degradation of HDAC1 Am. J. Respir. Cell Mol. Biol., August 1, 2007; 37(2): 232 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Celli and P. J. Barnes Exacerbations of chronic obstructive pulmonary disease Eur. Respir. J., June 1, 2007; 29(6): 1224 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tsoumakidou, W. Elston, J. Zhu, Z. Wang, E. Gamble, N. M. Siafakas, N. C. Barnes, and P. K. Jeffery Cigarette Smoking Alters Bronchial Mucosal Immunity in Asthma Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 919 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Li, A. Samanta, X. Song, K. T. Iacono, K. Bembas, R. Tao, S. Basu, J. L. Riley, W. W. Hancock, Y. Shen, et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression PNAS, March 13, 2007; 104(11): 4571 - 4576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Keslacy, O. Tliba, H. Baidouri, and Y. Amrani Inhibition of Tumor Necrosis Factor-{alpha}-Inducible Inflammatory Genes by Interferon-{gamma} Is Associated with Altered Nuclear Factor-{kappa}B Transactivation and Enhanced Histone Deacetylase Activity Mol. Pharmacol., February 1, 2007; 71(2): 609 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P J Barnes Theophylline for COPD. Thorax, September 1, 2006; 61(9): 742 - 743. [Full Text] [PDF]
|
|
|
|
|
|
T Hirano, T Yamagata, M Gohda, Y Yamagata, T Ichikawa, S Yanagisawa, K Ueshima, K Akamatsu, M Nakanishi, K Matsunaga, et al. Inhibition of reactive nitrogen species production in COPD airways: comparison of inhaled corticosteroid and oral theophylline. Thorax, September 1, 2006; 61(9): 761 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yin, L. Gonzales, V. Kolla, N. Rath, Y. Zhang, M. M. Lu, S. Kimura, P. L. Ballard, M. F. Beers, J. A. Epstein, et al. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression Am J Physiol Lung Cell Mol Physiol, August 1, 2006; 291(2): L191 - L199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hew, P. Bhavsar, A. Torrego, S. Meah, N. Khorasani, P. J. Barnes, I. Adcock, K. Fan Chung, and for the National Heart Lung and Blood Institute's Relative Corticosteroid Insensitivity of Peripheral Blood Mononuclear Cells in Severe Asthma Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 134 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rahman and I. M. Adcock Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J., July 1, 2006; 28(1): 219 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe Update in chronic obstructive pulmonary disease 2005. Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065. [Full Text] [PDF]
|
|
|
|
|
|
H. Slevogt, B. Schmeck, C. Jonatat, J. Zahlten, W. Beermann, V. van Laak, B. Opitz, S. Dietel, P. D. N'Guessan, S. Hippenstiel, et al. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-{kappa}B activation and histone deacetylase activity reduction Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L818 - L826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xu, P. K. Sengupta, E. Seto, and B. D. Smith Regulatory Factor for X-box Family Proteins Differentially Interact with Histone Deacetylases to Repress Collagen {alpha}2(I) Gene (COL1A2) Expression J. Biol. Chem., April 7, 2006; 281(14): 9260 - 9270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes Corticosteroid effects on cell signalling Eur. Respir. J., February 1, 2006; 27(2): 413 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes Reduced Histone Deacetylase in COPD: Clinical Implications Chest, January 1, 2006; 129(1): 151 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Stock, O. Akbari, R. H. DeKruyff, and D. T. Umetsu Respiratory Tolerance Is Inhibited by the Administration of Corticosteroids J. Immunol., December 1, 2005; 175(11): 7380 - 7387. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
