|
 |
|
|||||||
|
|||||||||
Copyright ©ERS Journals Ltd 2005
Blunted 
T-lymphocyte response in chronic obstructive pulmonary disease
1 Unidad de Investigación, 2 Inmunología, 3 Neumología, and 4 Análisis Clinicos, Hospital Universitario Son Dureta, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Palma de Mallorca, Spain
CORRESPONDENCE: A. G. N. Agustí, Servei de Pneumologia, Hospital Universitari Son Dureta, Andrea Doria 55, 07014- Palma de Mallorca, Spain. Fax: 34 971175228. E-mail: aagusti@hsd.es
Keywords: Flow cytometry, lung inflammation, mucosal homeostasis, tissue repair
Received: June 10, 2004
Accepted November 28, 2004
Chronic obstructive pulmonary disease (COPD) is characterised by an excessive inflammatory response to inhaled particles, mostly tobacco smoking. Although inflammation is present in all smokers, only a percentage of them develop COPD. T-lymphocytes are important effector and regulatory cells that participate actively in the inflammatory response of COPD. They comprise the T-cell receptor (TCR)-
To investigate TCR-
The present study found that: 1) the distribution of CD4+ and CD8+ lymphocytes in blood and BAL was similar in all three groups; 2) compared with nonsmokers,
These results highlight a novel, potentially relevant, pathogenic mechanism in chronic obstructive pulmonary disease.
ß (CD4+ and CD8+) and TCR-
T-lymphocytes. The latter represent a small percentage of the total T-cell population, but play a key role in tissue repair and mucosal homeostasis. ß (CD4+ and CD8+) and TCR- T-lymphocytes in COPD, the present authors determined, by flow cytometry, the distribution of both subpopulations in peripheral blood and bronchoalveolar lavage (BAL) samples obtained from patients with COPD, smokers with normal lung function and never-smokers. T-lymphocytes were significantly increased in smokers with preserved lung function; and 3) this response was blunted in patients with COPD.
This article has been cited by other articles:
|
|
 |
|
  M. G. Cosio, M. Saetta, and A. Agusti Immunologic Aspects of Chronic Obstructive Pulmonary Disease N. Engl. J. Med., June 4, 2009; 360(23): 2445 - 2454. [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes and B. R. Celli Systemic manifestations and comorbidities of COPD Eur. Respir. J., May 1, 2009; 33(5): 1165 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Isajevs, I. Taivans, G. Strazda, U. Kopeika, M. Bukovskis, V. Gordjusina, and A. Kratovska Decreased FOXP3 expression in small airways of smokers with COPD Eur. Respir. J., January 1, 2009; 33(1): 61 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Barcelo, J. Pons, J. M. Ferrer, J. Sauleda, A. Fuster, and A. G. N. Agusti Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking Eur. Respir. J., March 1, 2008; 31(3): 555 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshikawa, G. Dent, J. Ward, G. Angco, G. Nong, N. Nomura, K. Hirata, and R. Djukanovic Impaired Neutrophil Chemotaxis in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., March 1, 2007; 175(5): 473 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Wands, C. L. Roark, M. K. Aydintug, N. Jin, Y.-S. Hahn, L. Cook, X. Yin, J. Dal Porto, M. Lahn, D. M. Hyde, et al. Distribution and leukocyte contacts of {gamma}{delta} T cells in the lung J. Leukoc. Biol., November 1, 2005; 78(5): 1086 - 1096. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |