HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Berghmans, T. Articles by Sculier, J. P. Search for Related Content PubMed PubMed Citation Articles by Berghmans, T. Articles by Sculier, J. P.

Prognostic role of epidermal growth factor receptor in stage III nonsmall cell lung cancer

¹ Dept of Critical Care and Thoracic Oncology, Institut Jules Bordet, and ² Dept of Pneumology, Hôpital Saint-Pierre, Brussels, Belgium

CORRESPONDENCE: T. Berghmans, Institut Jules Bordet, Rue Héger-Bordet 1, 1000 Bruxelles, Belgium. Fax: 32 25343756. E-mail: thierry.berghmans@bordet.be

Keywords: Epidermal growth factor receptor, nonsmall cell lung cancer, prognostic factors, staging

Received: May 21, 2004
Accepted October 28, 2004

New biological factors have not been extensively studied in stage III nonsmall cell lung cancer (NSCLC). The aim of the present retrospective study was to determine the role of epidermal growth factor receptor (EGF-R) as a prognostic factor in stage III NSCLC, in addition to the stage and other known clinical factors.

Clinical characteristics were retrieved from the patients' charts. Membrane immunostaining for EGF-R was evaluated by three independent observers. The Cox multivariate model, including all variables with a p-value of <0.2 in univariate analysis, was used to assess the impact of clinical and biological factors on patients survival.

Between January 1987 and July 2002, 99 assessable stage III NSCLC patients were included in the study. A total of 23 patients were positive for EGF-R (squamous 39.6% versus nonsquamous 7.8%). In multivariate analysis, only three factors were statistically significantly associated with survival: performance status, surgery and creatinine.

In conclusion, good performance status, surgical resection and creatinine were found to be independent favourable prognostic factors for survival in a retrospective analysis of stage III nonsmall cell lung cancer, while epidermal growth factor receptor was not even in the univariate analysis.

This article has been cited by other articles:

				C-Q Zhu, W Shih, C-H Ling, and M-S Tsao Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation. J. Clin. Pathol., August 1, 2006; 59(8): 790 - 800. [Abstract] [Full Text] [PDF]