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1 Dept of Medicine, Division of Pulmonary and Critical Care Medicine, and 2 Dept of Biostatistics, University of Washington, Seattle, WA, USA
CORRESPONDENCE: G. Raghu, Chest Clinic, Interstitial Lung Disease, Sarcoid and Pulmonary Fibrosis Program, University of Washington Medical Center, Box 356522, BB-1253 HSC, 1959 NE Pacific Street, Seattle, WA 98195-6522, USA. Fax: 1 2066858673. E-mail: graghu@u.washington.edu
Keywords: Idiopathic pulmonary fibrosis, interstitial lung disease, pulmonary function, survival, walk test
Received: December 11, 2003
Accepted August 30, 2004
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive disease with a median survival of
The study population consisted of 28 patients with well-characterised progressive IPF. The timed walk test and concurrent measures of disease severity were assessed at baseline. Participants were prospectively followed for
There were strong correlations between the end-exercise saturation and walk-velocity parameters of the timed walk test and diffusing capacity, and arterial oxygen tension at rest. In univariate Cox proportional-hazards models, end-exercise saturation, change in saturation with exercise, walk distance and walk velocity were associated with survival. In unadjusted logistic regression models, odds of death at 2 yrs were associated with the same parameters.
In conclusion, the timed walk test relates to disease severity and long-term outcome in progressive idiopathic pulmonary fibrosis.
3 yrs. Measurements of airflow and lung volumes at rest are generally used to monitor the clinical course in this disorder. This study was designed to determine if a modified version of the 6-min walk test, called the timed walk test, accurately characterises disease severity and survival in IPF. 
4 yrs to determine the relationship between parameters of the timed walk test and survival.
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