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Copyright ©ERS Journals Ltd 2005
Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants
Dipartimento di Fisiopatologia e Medicina Sperimentale, Università di Siena, Siena, Italy
CORRESPONDENCE: G. Lungarella, Dipartimento di Fisiopatologia e Medicina Sperimentale, Università di Siena, Via Aldo Moro n.6, I-53100 Siena, Italy. Fax: 39 0577234019. E-mail: lungarella@unisi.it
Keywords: Bronchial changes, emphysema, expression of cytokines, mouse interstrain variations
Received: June 7, 2004
Accepted August 13, 2004
The development of cigarette smoke-induced pulmonary changes in C57 Bl/6J and DBA/2 mice was investigated. Both strains are sensitive to oxidants and C57Bl/6J mice are moderately deficient in serum alpha1-proteinase inhibitor.
Following chronic exposure to cigarette smoke, patchy emphysema was present in mice of both strains, but developed faster in DBA/2 mice. A positive reaction for mouse neutrophil elastase was seen on the septa of both strains. Additionally, the DBA/2 mice developed a uniform parenchymal dilation that was preceded by the appearance of apoptotic cells in areas with a low signal for vascular endothelial growth factor-receptor 2. Fibrotic areas scattered throughout the parenchyma, coupled with a positive immunohistochemical reaction for transforming growth factor-ß was seen only in DBA/2 mice.
Both DBA/2 and C57Bl/6J strains showed epithelial cell injury and areas of deciliation in their airways. However, the appearance of goblet cell metaplasia was common in C57Bl/6J mice but rare in DBA/2 mice. A positive immunohistochemical reaction for interleukin (IL)-4, IL-13 and MUC5AC was seen only in the airways of C57Bl/6J mice.
Strain characteristics (alpha1-proteinase inhibitor levels, sensitivity to oxidants, and constitutive levels of vascular endothelial growth factor-receptor 2) and phenotypical responses (apoptosis and cytokine distribution) may condition parenchymal and airway changes to cigarette smoke.
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