| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 First Dept of Medicine, Hokkaido University School of Medicine and 2 Dept of Biochemistry, Sapporo Medical College, Sapporo, Japan
CORRESPONDENCE: T. Betsuyaku, First Dept of Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan. Fax: 81 117067899. E-mail: bytomoko@med.hokudai.ac.jp
Keywords: Ageing, chronic obstructive pulmonary disease, collectin, pulmonary emphysema, sequential bronchoalveolar lavage, smoking
Received: June 1, 2004
Accepted August 6, 2004
This research was supported by the Respiratory Failure Research Group of the Ministry of Health, Labor, and Welfare of Japan (to M. Nishimura) and scientific research grant 14570532 from the Ministry of Education, Science, Culture and Sports of Japan (to T. Betsuyaku).
Surfactant protein (SP)-A and SP-D are collagen-like glycoproteins that are synthesised in the distal pulmonary epithelium. This study examined the effects of ageing and long-term smoking on SP-A and SP-D in the lungs. The possible links to the development of pulmonary emphysema were also investigated.
Sequential lavage was performed in young and middle-aged or elderly nonsmokers and asymptomatic current smokers with various smoking histories. Middle-aged or elderly smokers were further categorised according to the presence of emphysema by high-resolution computed tomography. Levels of SP-A and SP-D in bronchial lavage (BL) fluid and in bronchoalveolar lavage (BAL) fluid were quantified by ELISA.
Significant decreases in SP-A were seen with age in nonsmokers in BL fluid, but not in BAL fluid. Middle-aged or elderly smokers with emphysema had lower levels of SP-A in both BL and BAL fluids when compared with young subjects, and in BL fluid when compared with middle-aged or elderly smokers without emphysema. SP-D did not change with age alone, however, it was decreased in middle-aged or elderly smokers when compared with similarly aged nonsmokers.
In conclusion, surfactant protein-A may decrease with age alone or due to the cumulative effects of long-term smoking and development of emphysema, while surfactant protein-D decreases due to long-term smoking.
This article has been cited by other articles:
|
|
 |
|
  D. D. Sin, P. S. Pahlavan, and S.F. P. Man Review: Surfactant protein D: A lung specific biomarker in COPD? Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 65 - 74. [Abstract] [PDF]
|
|
|
|
 |
|
 H. R. S. Tagaram, G. Wang, T. M. Umstead, A. N. Mikerov, N. J. Thomas, G. R. Graff, J. C. Hess, M. J. Thomassen, M. S. Kavuru, D. S. Phelps, et al. Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1052 - L1063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ueda, M. Jinbo, T.-S. Li, T. Yagi, K. Suga, and K. Hamano Computed Tomography-Diagnosed Emphysema, Not Airway Obstruction, Is Associated with the Prognostic Outcome of Early-Stage Lung Cancer. Clin. Cancer Res., November 15, 2006; 12(22): 6730 - 6736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Henson, R. W. Vandivier, and I. S. Douglas Cell Death, Remodeling, and Repair in Chronic Obstructive Pulmonary Disease? Proceedings of the ATS, November 1, 2006; 3(8): 713 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Nagai, T Betsuyaku, T Kondo, Y Nasuhara, and M Nishimura Long term smoking with age builds up excessive oxidative stress in bronchoalveolar lavage fluid Thorax, June 1, 2006; 61(6): 496 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Sorensen, J. v. B. Hjelmborg, K. O. Kyvik, M. Fenger, A. Hoj, C. Bendixen, T. I. A. Sorensen, and U. Holmskov Genetic and environmental influences of surfactant protein D serum levels Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L1010 - L1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nagai, T. Betsuyaku, Y. Ito, Y. Nasuhara, and M. Nishimura Decrease of vascular endothelial growth factor in macrophages from long-term smokers Eur. Respir. J., April 1, 2005; 25(4): 626 - 633. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
