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Paediatric lung transplantation

¹ Lung Transplant Program, Texas Children's Hospital, Houston, TX, and ² Division of Cardiothoracic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

CORRESPONDENCE: G.B. Mallory, Texas Children's Hospital, 6621 Fannin, CC 1040.00, Houston, TX 77030, USA. Fax: 1 8328253308. E-mail: gbmallor@texaschildrenshospital.org

Keywords: Cystic fibrosis, heart-lung transplantation, living donor lung transplantation, lung transplantation, paediatrics

Received: June 2, 2004
Accepted June 6, 2004

Abstract

Since 1990, lung transplantation has been performed in infants, children and adolescents in small numbers, and the numbers, in comparison with adult transplants, remain small today. The indications for lung transplantation are similar in childhood when compared with adults, but the disease entities are distinct.

In children, severe pulmonary vascular disease is most commonly associated with developmental abnormalities or congenital heart disease, as opposed to idiopathic pulmonary hypertension. Cystic fibrosis is the dominant indication for lung transplantation in older childhood and adolescence.

The operative approach to lung transplantation in early life differs from that in adults, in that cardiopulmonary bypass is more likely to be utilised and bilateral lung transplantation is strongly preferred to single lung transplantation. Living donor lung transplantation is proportionately more common in children and adolescents than in adults. Post-transplant complications related to viral infection and post-transplant lymphoproliferative disease are more common and more likely to be severe and life-threatening. Bronchiolitis obliterans is the most important complication after paediatric lung transplantation and limits both the quality of life and duration of survival, as in adults.

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