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Eur Respir J 2004; 24:790-797
Copyright ©ERS Journals Ltd 2004

Morning levels of fibrinogen in children with sleep-disordered breathing

A.G. Kaditis1,4, E.I. Alexopoulos1,4, E. Kalampouka1,4, E. Kostadima5, N. Angelopoulos5, A. Germenis2, E. Zintzaras3 and K. Gourgoulianis5

Depts of 1 Paediatrics, 2 Immunology and 3 Biomathematics, 4 Paediatric Pulmonology Unit, and 5 Sleep Disorders Laboratory, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece.

CORRESPONDENCE: A.G. Kaditis, Dept of Paediatrics, Larissa University Hospital, P.O. Box 1425, Larissa 41110, Greece. Fax: 30 2410611097. E-mail: KADITIA@hotmail.com

Keywords: Obstructive sleep apnoea, polysomnography, snoring

Received: January 24, 2004
Accepted July 6, 2004

Elevated fibrinogen level is a predictor of cardiovascular disease in adults, and it is associated with sleep-disordered breathing. Levels of fibrinogen in adults are affected by other co-existing cardiovascular risk factors, which are not usually present in children.

To investigate the association between fibrinogen and sleep-disordered breathing, a case-control study was carried out in children with and without habitual snoring. All snoring children underwent polysomnography.

Morning fibrinogen values in 30 children with snoring and an apnoea-hypopnoea index (AHI) ≥5 episodes·h–1 (median (interquartile range) 318 mg·dL–1 (290–374)) were similar to values in 61 children with snoring and an AHI <5 episodes·h–1 (307 (269–346)). Both groups had higher fibrinogen values than those in 23 controls without snoring (271 mg·dL–1 (244–294)). There was no correlation between fibrinogen values and AHI, respiratory movement/arousal index or haemoglobin desaturation index.

In conclusion, fibrinogen values are higher in children with snoring than in controls, but there is no association between these values and polysomnography indices.




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