HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by McElroy, M.C. Articles by Kasper, M. Search for Related Content PubMed PubMed Citation Articles by McElroy, M.C. Articles by Kasper, M.

The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair

¹ MRC Centre for Inflammation Research, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, UK. ² Dept of Anatomy, Carl Gustav Carus Medical Faculty, Technical University of Dresden, Dresden, Germany.

CORRESPONDENCE: M.C. McElroy, MRC Centre for Inflammation Research, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, EH8 9AG, UK. Fax: 44 1316506528. E-mail: mmcelroy@ed.ac.uk

Keywords: Alveolar epithelial type I cell, cell differentiation, fibrosis, marker, primary acute respiratory distress syndrome, pulmonary injury

Received: August 21, 2003
Accepted April 29, 2004

M.C. McElroy is funded by the Norman Salvesen Emphysema Research Fund (Edinburgh, UK) and M. Kasper by the Deutsche Forschungsgemeinschaft (SFB 13) (Bonn, Germany).

Abstract

Alveolar epithelial type I cells cover most of the internal surface area of the lungs.

Ultrastructural studies demonstrate that alveolar epithelial type I cell damage is frequently observed in acute and chronic lung diseases.

This article discusses the use of cell-selective proteins as markers for the investigation of injury and repair of the alveolar epithelium. The utility of proteins specific to alveolar epithelial type I cells as diagnostic markers of alveolar epithelial injury in acute lung injury is considered, and expression of proteins selective for alveolar epithelial type I cells in lungs following injury and in fibrosis are discussed.

This article has been cited by other articles:

				S. R. Bates, J.-Q. Tao, K. J. Yu, Z. Borok, E. D. Crandall, H. L. Collins, and G. H. Rothblat Expression and Biological Activity of ABCA1 in Alveolar Epithelial Cells Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 283 - 292. [Abstract] [Full Text] [PDF]

				T. Uchida, M. Shirasawa, L. B. Ware, K. Kojima, Y. Hata, K. Makita, G. Mednick, Z. A. Matthay, and M. A. Matthay Receptor for Advanced Glycation End-Products Is a Marker of Type I Cell Injury in Acute Lung Injury Am. J. Respir. Crit. Care Med., May 1, 2006; 173(9): 1008 - 1015. [Abstract] [Full Text] [PDF]

				R. L. Auten, M. A. O'Reilly, T. D. Oury, E. Nozik-Grayck, and M. H. Whorton Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L32 - L40. [Abstract] [Full Text] [PDF]

				G. R. Clegg, C. Tyrrell, S. R. McKechnie, M. F. Beers, D. Harrison, and M. C. McElroy Coexpression of RTI40 with alveolar epithelial type II cell proteins in lungs following injury: identification of alveolar intermediate cell types Am J Physiol Lung Cell Mol Physiol, September 1, 2005; 289(3): L382 - L390. [Abstract] [Full Text] [PDF]