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Lung function 5 yrs after allogeneic bone marrow transplantation conditioned with busulphan and cyclophosphamide

¹ Dept of Respiratory Medicine, Division of Heart and Lung Diseases, and ² Section of Haematology, Medical Dept, The National Hospital, University of Oslo, Norway

CORRESPONDENCE: J. Boe, Dept of Respiratory Medicine, Division of Heart and Lung Diseases, The National Hospital, University of Oslo, N-0027 Oslo, Norway. Fax: 47 23073917, E-mail: jacob.boe@klinmed.uio.no

Keywords: Allogeneic, bone marrow transplantation, busulphan, cyclophosphamide, long term, pulmonary function

Received: July 22, 2003
Accepted February 2, 2004

Long-term data on lung function after bone marrow transplantation (BMT) are inconclusive. Previously, a persistent reduction in gas transfer 1 yr after allogeneic BMT with busulphan and cyclophosphamide conditioning was reported by the current authors. In the present study this reduction was examined to see if it was permanent, transient or progressive.

Prospectively, 43 consecutive adult patients with malignant blood disorders undertook lung function measurements prior to BMT, at 3 month intervals during the 1st yr after BMT and finally after 5 yrs.

Mean baseline lung function values were >90% predicted. Within the 1st yr after BMT a transient decline in lung volumes and a persistent reduction in gas transfer were observed. After 5 yrs, baseline values were restored for all variables, except in four patients who developed obliterative bronchiolitis. Acute leukaemia and smoking were independently associated with gas transfer reductions at baseline and during the 1st yr after BMT.

Allogeneic bone marrow transplantation with busulphan and cyclophosphamide conditioning was associated with a reduction in gas transfer 1 yr after bone marrow transplantation but baseline values were usually restored after 5 yrs. Since recovery may be gradual and slow, an observation period >1 yr is required before drawing conclusions concerning the development of a permanent reduction in lung function after allogeneic bone marrow transplantation conditioned with busulphan and cyclophosphamide.