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1 University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado, USA. 2 University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada. 3 Boston University School of Medicine, Boston, MA, USA
CORRESPONDENCE: J.D. Newell, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. Fax: 1 3033981652. E-mail: newellj@njc.org
Keywords: 
1-Antitrypsin deficiency, computed tomography, emphysema, trials of therapy
Received: April 24, 2003
Accepted January 19, 2004
This workshop was funded by the following organisations: AlphaNet, American Red Cross, Aventis Behring LLC, Bayer Corporation, Grifols, Ono Pharmaceuticals USA and Roche Bioscience.
Abstract
It has been reported that quantitative computed tomography (CT) scanning of the lungs showed decreased progression of emphysema in a randomised clinical trial in patients with severe
Accordingly, the Alpha-1 Foundation convened a workshop to explore the feasibility of using quantitative CT data as a primary outcome variable in trials of drugs for treating
This report reviews the following: the principles for the use of modern CT scanners for quantifying emphysema; the methods and data on validation by comparison with measurements of severity of emphysema in inflation-fixed specimens of lungs; and the possibility of decreasing radiation dosage from CT to make it safe and ethically possible to use CT in longitudinal studies.
The workshop concluded that it is feasible, safe and ethically possible to use computed tomography in longitudinal studies of emphysema. It recommended that the primary end-point should be a significant shift in the 15th percentile of lung density.
1-antitrypsin (1-AT) deficiency receiving monthly intravenous augmentation therapy with human 1-AT. Comparable results were not obtained using rate of decline of forced expiratory volume in one second. 1-AT deficiency.
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