ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Permissions
Right arrowRequest Permissions
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (83)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dartevelle, P.
Right arrow Articles by Simonneau, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dartevelle, P.
Right arrow Articles by Simonneau, G.
Eur Respir J 2004; 23:637-648
Copyright ©ERS Journals Ltd 2004

Chronic thromboembolic pulmonary hypertension

P. Dartevelle1, E. Fadel1, S. Mussot1, A. Chapelier1, P. Hervé1, M. de Perrot1, J. Cerrina1, F.L. Ladurie1, D. Lehouerou1, M. Humbert2, O. Sitbon2 and G. Simonneau2

1 Dept of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, Paris-Sud University, Le Plessis, Robinson and 2 Service de Pneumologie et Réanimation Respiratoire, Hôpital Antoine Béclère, Paris-Sud University, Clamart, France

CORRESPONDENCE: P. Dartevelle, Dept of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Marie Lannelongue Hospital, 133, Avenue de la Résistance, 92350, Le Plessis Robinson, France. Fax: 33 140945583. E-mail: pdartevelle@ccml.com

Keywords: pulmonary arterial hypertension, pulmonary embolism, pulmonary thromboendarterectomy

Received: July 9, 2003
Accepted November 25, 2003

Abstract

Pulmonary arterial hypertension is a severe disease that has been ignored for a long time. However, over the past 20 yrs chest physicians, cardiologists and thoracic surgeons have shown increasing interest in this disease because of the development of new therapies, that have improved both the outcome and quality of life of patients, including pulmonary transplantation and prostacyclin therapy.

Chronic thromboembolic pulmonary arterial hypertension (CTEPH) can be cured surgically through a complex surgical procedure: the pulmonary thromboendarterectomy. Pulmonary thromboendarterectomy is performed under hypothermia and total circulatory arrest.

Due to clinically evident acute-pulmonary embolism episodes being absent in >50% of patients, the diagnosis of CTEPH can be difficult. Lung scintiscan showing segmental mismatched perfusion defects is the best diagnostic tool to detect CTEPH.

Pulmonary angiography confirms the diagnosis and determines the feasability of endarterectomy according to the location of the disease, proximal versus distal. The technique of angiography must be perfect with the whole arterial tree captured on the same picture for each lung. The lesions must start at the level of the pulmonary artery trunk, or at the level of the lobar arteries, in order to find a plan for the endarterectomy.

When the haemodynamic gravity corresponds to the degree of obliteration, pulmonary thromboendarterectomy can be performed with minimal perioperative mortality, providing definitive, excellent functional results in almost all cases.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. J. Reesink, S. Surie, J. J. Kloek, H. L. Tan, R. Tepaske, P. F. Fedullo, and P. Bresser
Bosentan as a bridge to pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension
J. Thorac. Cardiovasc. Surg., January 1, 2010; 139(1): 85 - 91.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
The Task Force for the Diagnosis and Treatment of, N. Galie, M. M. Hoeper, M. Humbert, A. Torbicki, J-L. Vachiery, J. A. Barbera, M. Beghetti, P. Corris, S. Gaine, et al.
Guidelines for the diagnosis and treatment of pulmonary hypertension
Eur. Respir. J., December 1, 2009; 34(6): 1219 - 1263.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
Authors/Task Force Members, N. Galie, M. M. Hoeper, M. Humbert, A. Torbicki, J.-L. Vachiery, J. A. Barbera, M. Beghetti, P. Corris, S. Gaine, et al.
Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
Eur. Heart J., October 2, 2009; 30(20): 2493 - 2537.
[Full Text] [PDF]

Home page
 ICVTSHome page
K. Ishida, M. Masuda, H. Tanaka, M. Imamaki, M. Katsumata, T. Maruyama, and M. Miyazaki
Mid-term results of surgery for chronic thromboembolic pulmonary hypertension
Interactive CardioVascular and Thoracic Surgery, October 1, 2009; 9(4): 626 - 629.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
O. Sanchez, B. Planquette, and G. Meyer
Update on acute pulmonary embolism
Eur. Respir. Rev., September 1, 2009; 18(113): 137 - 147.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
G. Simonneau, I. M. Robbins, M. Beghetti, R. N. Channick, M. Delcroix, C. P. Denton, C. G. Elliott, S. P. Gaine, M. T. Gladwin, Z.-C. Jing, et al.
Updated clinical classification of pulmonary hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S43 - S54.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. M. Keogh, E. Mayer, R. L. Benza, P. Corris, P. G. Dartevelle, A. E. Frost, N. H. Kim, I. M. Lang, J. Pepke-Zaba, and J. Sandoval
Interventional and surgical modalities of treatment in pulmonary hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S67 - S77.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. M. Hoeper, J. A. Barbera, R. N. Channick, P. M. Hassoun, I. M. Lang, A. Manes, F. J. Martinez, R. Naeije, H. Olschewski, J. Pepke-Zaba, et al.
Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S85 - S96.
[Abstract] [Full Text] [PDF]

Home page
 MMCTSHome page
M. Berman, E. Pavlushkov, E. Abraham, J. Dunning, S. Tsui, R. Hall, A. Klein, and D. P. Jenkins
Pulmonary endarterectomy - an example of treatment of right ventricular after load failure
MMCTS, June 12, 2009; 2009(0612): 3491.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
N. Saouti, W. J. Morshuis, R. H. Heijmen, and R. J. Snijder
Long-term outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a single institution experience
Eur. J. Cardiothorac. Surg., June 1, 2009; 35(6): 947 - 952.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
M. Humbert
More pressure on pulmonary hypertension
Eur. Respir. Rev., March 1, 2009; 18(111): 1 - 3.
[Full Text] [PDF]

Home page
 ERRHome page
I. M. Lang
Managing chronic thromboembolic pulmonary hypertension: pharmacological treatment options
Eur. Respir. Rev., March 1, 2009; 18(111): 24 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Couturaud, I. Frachon, and C. Leroyer
Chronic thromboembolic pulmonary hypertension: a tribute to pulmonary endarterectomy
Eur. Respir. J., February 1, 2009; 33(2): 230 - 232.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
D. Bonderman, H. Wilkens, S. Wakounig, H-J. Schafers, P. Jansa, J. Lindner, I. Simkova, A. M. Martischnig, J. Dudczak, R. Sadushi, et al.
Risk factors for chronic thromboembolic pulmonary hypertension
Eur. Respir. J., February 1, 2009; 33(2): 325 - 331.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Condliffe, D. G. Kiely, J. S. R. Gibbs, P. A. Corris, A. J. Peacock, D. P. Jenkins, K. Goldsmith, J. G. Coghlan, and J. Pepke-Zaba
Prognostic and aetiological factors in chronic thromboembolic pulmonary hypertension
Eur. Respir. J., February 1, 2009; 33(2): 332 - 338.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
E. Castaner, X. Gallardo, E. Ballesteros, M. Andreu, Y. Pallardo, J. M. Mata, and L. Riera
CT Diagnosis of Chronic Pulmonary Thromboembolism1
RadioGraphics, January 1, 2009; 29(1): 31 - 50.
[Abstract] [Full Text] [PDF]

Home page
 ESC Textbook of Cardiovascular MedicineHome page
N. Galiè and A. Manes
CHAPTER 24 Pulmonary Hypertension
ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
X. Jais, A. M. D'Armini, P. Jansa, A. Torbicki, M. Delcroix, H. A. Ghofrani, M. M. Hoeper, I. M. Lang, E. Mayer, J. Pepke-Zaba, et al.
Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial.
J. Am. Coll. Cardiol., December 16, 2008; 52(25): 2127 - 2134.
[Abstract] [Full Text] [PDF]

Home page
 J Ultrasound MedHome page
H.-M. Chen, Y.-Y. Duan, L.-J. Yuan, N. Zhou, J. Li, Y.-H. Yang, T.-S. Cao, and Y. Wang
Superior Vena Cava Doppler Flow Changes in Rabbits With Acute Thromboembolic Pulmonary Hypertension
J. Ultrasound Med., December 1, 2008; 27(12): 1711 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. Berman, S. Tsui, A. Vuylsteke, A. Snell, S. Colah, R. Latimer, R. Hall, J. E. Arrowsmith, J. Kneeshaw, A. A. Klein, et al.
Successful Extracorporeal Membrane Oxygenation Support After Pulmonary Thromboendarterectomy
Ann. Thorac. Surg., October 1, 2008; 86(4): 1261 - 1267.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
P. M. Mikus, E. Mikus, S. Martin-Suarez, N. Galie, A. Manes, S. Pastore, and G. Arpesella
Pulmonary endarterectomy: an alternative to circulatory arrest and deep hypothermia: mid-term results
Eur. J. Cardiothorac. Surg., July 1, 2008; 34(1): 159 - 163.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J.-W. Lankhaar, N. Westerhof, T. J.C. Faes, C. Tji-Joong Gan, K. M. Marques, A. Boonstra, F. G. van den Berg, P. E. Postmus, and A. Vonk-Noordegraaf
Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension
Eur. Heart J., July 1, 2008; 29(13): 1688 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Heart, March 1, 2008; 94(Suppl_1): i1 - i41.
[Full Text] [PDF]

Home page
 ThoraxHome page
National Pulmonary Hypertension Centres of the UK
Consensus statement on the management of pulmonary hypertension in clinical practice in the UK and Ireland
Thorax, March 1, 2008; 63(Suppl_2): ii1 - ii41.
[Full Text] [PDF]

Home page
 ChestHome page
M. de Perrot, E. Fadel, K. McRae, K. Tan, P. Slinger, N. Paul, S. Mak, and J. T. Granton
Evaluation of Persistent Pulmonary Hypertension After Acute Pulmonary Embolism
Chest, September 1, 2007; 132(3): 780 - 785.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. J. Reesink, I. I. Tulevski, J. T. Marcus, F. Boomsma, J. J. Kloek, A. Vonk Noordegraaf, and P. Bresser
Brain Natriuretic Peptide as Noninvasive Marker of the Severity of Right Ventricular Dysfunction in Chronic Thromboembolic Pulmonary Hypertension
Ann. Thorac. Surg., August 1, 2007; 84(2): 537 - 543.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Humbert
The burden of pulmonary hypertension
Eur. Respir. J., July 1, 2007; 30(1): 1 - 2.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
A. J. Peacock, N. F. Murphy, J. J. V. McMurray, L. Caballero, and S. Stewart
An epidemiological study of pulmonary arterial hypertension
Eur. Respir. J., July 1, 2007; 30(1): 104 - 109.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
N. Tunariu, S. J.R. Gibbs, Z. Win, W. Gin-Sing, A. Graham, P. Gishen, and A. AL-Nahhas
Ventilation-Perfusion Scintigraphy Is More Sensitive than Multidetector CTPA in Detecting Chronic Thromboembolic Pulmonary Disease as a Treatable Cause of Pulmonary Hypertension
J. Nucl. Med., May 1, 2007; 48(5): 680 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
M. Hardziyenka, H. J. Reesink, B. J. Bouma, H.A.C.M. R. de Bruin-Bon, M. E. Campian, M. W.T. Tanck, R. B.A. van den Brink, J. J. Kloek, H. L. Tan, and P. Bresser
A novel echocardiographic predictor of in-hospital mortality and mid-term haemodynamic improvement after pulmonary endarterectomy for chronic thrombo-embolic pulmonary hypertension
Eur. Heart J., April 1, 2007; 28(7): 842 - 849.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J.-F. Paul, A. Khallil, A. Sigal-Cinqualbre, F. Leroy-Ladurie, J. Cerrina, E. Fadel, and P. Dartevelle
Findings on Submillimeter MDCT Are Predictive of Operability in Chronic Thromboembolic Pulmonary Hypertension
Am. J. Roentgenol., April 1, 2007; 188(4): 1059 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. M. D'Armini, G. Zanotti, S. Ghio, G. Magrini, M. Pozzi, L. Scelsi, G. Meloni, C. Klersy, and M. Vigano
Reverse right ventricular remodeling after pulmonary endarterectomy
J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 162 - 168.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Matsuda, H. Ogino, K. Minatoya, H. Sasaki, N. Nakanishi, S. Kyotani, J. Kobayashi, T. Yagihara, and S. Kitamura
Long-term recovery of exercise ability after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension.
Ann. Thorac. Surg., October 1, 2006; 82(4): 1338 - 1343.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-W. Lankhaar, N. Westerhof, T. J. C. Faes, K. M. J. Marques, J. T. Marcus, P. E. Postmus, and A. Vonk-Noordegraaf
Quantification of right ventricular afterload in patients with and without pulmonary hypertension
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1731 - H1737.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. F. Tapson and M. Humbert
Incidence and Prevalence of Chronic Thromboembolic Pulmonary Hypertension: From Acute to Chronic Pulmonary Embolism
Proceedings of the ATS, September 1, 2006; 3(7): 564 - 567.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
N. Galie and N. H. S. Kim
Pulmonary Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension
Proceedings of the ATS, September 1, 2006; 3(7): 571 - 576.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
N. H. S. Kim
Assessment of Operability in Chronic Thromboembolic Pulmonary Hypertension
Proceedings of the ATS, September 1, 2006; 3(7): 584 - 588.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. Mayer and W. Klepetko
Techniques and Outcomes of Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension
Proceedings of the ATS, September 1, 2006; 3(7): 589 - 593.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. Bresser, J. Pepke-Zaba, X. Jais, M. Humbert, and M. M. Hoeper
Medical Therapies for Chronic Thromboembolic Pulmonary Hypertension: An Evolving Treatment Paradigm
Proceedings of the ATS, September 1, 2006; 3(7): 594 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
L. J. Rubin, M. M. Hoeper, W. Klepetko, N. Galie, I. M. Lang, and G. Simonneau
Current and Future Management of Chronic Thromboembolic Pulmonary Hypertension: From Diagnosis to Treatment Responses
Proceedings of the ATS, September 1, 2006; 3(7): 601 - 607.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Peacock, G. Simonneau, and L. Rubin
Controversies, Uncertainties and Future Research on the Treatment of Chronic Thromboembolic Pulmonary Hypertension
Proceedings of the ATS, September 1, 2006; 3(7): 608 - 614.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. M. Hoeper, E. Mayer, G. Simonneau, and L. J. Rubin
Chronic Thromboembolic Pulmonary Hypertension
Circulation, April 25, 2006; 113(16): 2011 - 2020.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. A. Thistlethwaite, A. Kemp, L. Du, M. M. Madani, and S. W. Jamieson
Outcomes of pulmonary endarterectomy for treatment of extreme thromboembolic pulmonary hypertension
J. Thorac. Cardiovasc. Surg., February 1, 2006; 131(2): 307 - 313.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
X Jais, V Ioos, C Jardim, O Sitbon, F Parent, A Hamid, E Fadel, P Dartevelle, G Simonneau, and M Humbert
Splenectomy and chronic thromboembolic pulmonary hypertension
Thorax, December 1, 2005; 60(12): 1031 - 1034.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. M. Hoeper, T. Kramm, H. Wilkens, C. Schulze, H. J. Schafers, T. Welte, and E. Mayer
Bosentan Therapy for Inoperable Chronic Thromboembolic Pulmonary Hypertension
Chest, October 1, 2005; 128(4): 2363 - 2367.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Heinrich, M. Uder, D. Tscholl, A. Grgic, B. Kramann, and H.-J. Schafers
CT Scan Findings in Chronic Thromboembolic Pulmonary Hypertension: Predictors of Hemodynamic Improvement After Pulmonary Thromboendarterectomy
Chest, May 1, 2005; 127(5): 1606 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Task Force members, N. Galie, A. Torbicki, R. Barst, P. Dartevelle, S. Haworth, T. Higenbottam, H. Olschewski, A. Peacock, G. Pietra, et al.
Guidelines on diagnosis and treatment of pulmonary arterial hypertension: The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology
Eur. Heart J., December 2, 2004; 25(24): 2243 - 2278.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
S.M. Kawut and H.I. Palevsky
New answers raise new questions in pulmonary arterial hypertension
Eur. Respir. J., June 1, 2004; 23(6): 799 - 801.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the European Respiratory Society.