ERJ
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koechlin, C.
Right arrow Articles by Préfaut, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koechlin, C.
Right arrow Articles by Préfaut, C.
Eur Respir J 2004; 23:538-544
Copyright ©ERS Journals Ltd 2004

Does systemic inflammation trigger local exercise-induced oxidative stress in COPD?

C. Koechlin1, A. Couillard1, J.P. Cristol2, P. Chanez3, M. Hayot1, D. Le Gallais4 and C. Préfaut1

1 Unité Propre de Recherche et d'Enseignement Supérieur Equipe d'Accueil 701, Laboratoire de Physiologie des Interactions, Service Central de Physiologie Clinique, Hospital Arnaud de Villeneuve, 2 Laboratoire de Biochimie des Lipides et du Stress Oxydant, Hospital Lapeyronie, 3 Service de Pneumologie, Hospital Arnaud de Villeneuve, and 4 Laboratoire Sport Performance Santé, Montpellier, France

CORRESPONDENCE: C. Koechlin, Laboratoire de Physiologie des Interactions, Service Central de Physiologie Clinique, Hôpital Arnaud de Villeneuve, 34295, Montpellier Cedex 5, France. Fax: 33 467335923. E-mail: christelle_koechlin@hotmail.com

Keywords: Cytokine, endurance, muscle, myopathy, superoxide anion

Received: June 18, 2003
Accepted October 31, 2003

Inflammatory abnormalities may be involved in the inadequate basal oxidant/antioxidant balance and local exercise-induced oxidative stress in chronic obstructive pulmonary disease (COPD) patients.

The time course of oxidative stress and inflammation was investigated in 10 COPD patients and seven healthy subjects before and after local dynamic quadriceps endurance exercise at 40% of maximal strength. Venous samples were collected before, immediately after and up to 48 h after exercise.

At rest, levels of an oxidant released by stimulated phagocytes, the superoxide anion, were significantly higher in patients, as were plasma levels of C-reactive protein, tumour necrosis factor-{alpha} and interleukin-6, inflammatory markers. An inverse relationship was found between baseline C-reactive protein levels and endurance time in patients. Six hours after exercise, superoxide anion release and levels of protein oxidation products, an index of oxidative stress, increased similarly in both groups, whereas thiobarbituric acid reactive substance levels, another index of oxidative stress, increased significantly only in patients. Plasma nonenzymatic antioxidant and inflammatory cytokine levels were unchanged by the exercise protocol.

The increased baseline systemic inflammation in chronic obstructive pulmonary disease patients could be related to disturbed oxidant/antioxidant balance, and, together, these may have triggered the exercise-induced oxidative stress. The absence, however, of local exercise-induced systemic inflammation suggests that additional mechanisms explain local exercise-induced oxidative stress.




This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
W. M. Chatila, B. M. Thomashow, O. A. Minai, G. J. Criner, and B. J. Make
Comorbidities in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, May 1, 2008; 5(4): 549 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. H. Remels, H. R. Gosker, P. Schrauwen, R. C. Langen, and A. M. Schols
Peroxisome proliferator-activated receptors: a therapeutic target in COPD?
Eur. Respir. J., March 1, 2008; 31(3): 502 - 508.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al.
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Eur. Respir. J., February 1, 2008; 31(2): 416 - 469.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E Barreiro, A M W J Schols, M I Polkey, J B Galdiz, H R Gosker, E B Swallow, C Coronell, J Gea, and on behalf of the ENIGMA in COPD project
Cytokine profile in quadriceps muscles of patients with severe COPD
Thorax, February 1, 2008; 63(2): 100 - 107.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe
Complex chronic comorbidities of COPD
Eur. Respir. J., January 1, 2008; 31(1): 204 - 212.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
I. Vogiatzis, G. Stratakos, D. C M Simoes, G. Terzis, O. Georgiadou, C. Roussos, and S. Zakynthinos
Effects of rehabilitative exercise on peripheral muscle TNF{alpha}, IL-6, IGF-I and MyoD expression in patients with COPD
Thorax, November 1, 2007; 62(11): 950 - 956.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Agusti
Thomas A. Neff Lecture. Chronic Obstructive Pulmonary Disease: A Systemic Disease
Proceedings of the ATS, August 1, 2006; 3(6): 478 - 481.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Rahman and I. M. Adcock
Oxidative stress and redox regulation of lung inflammation in COPD.
Eur. Respir. J., July 1, 2006; 28(1): 219 - 242.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. P. de Torres, E. Cordoba-Lanus, C. Lopez-Aguilar, M. Muros de Fuentes, A. Montejo de Garcini, A. Aguirre-Jaime, B. R. Celli, and C. Casanova
C-reactive protein levels and clinically important predictive outcomes in stable COPD patients
Eur. Respir. J., May 1, 2006; 27(5): 902 - 907.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Broekhuizen, E F M Wouters, E C Creutzberg, and A M W J Schols
Raised CRP levels mark metabolic and functional impairment in advanced COPD
Thorax, January 1, 2006; 61(1): 17 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Couillard and C. Prefaut
From muscle disuse to myopathy in COPD: potential contribution of oxidative stress
Eur. Respir. J., October 1, 2005; 26(4): 703 - 719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. Barreiro, B. de la Puente, J. Minguella, J. M. Corominas, S. Serrano, S. N. A. Hussain, and J. Gea
Oxidative Stress and Respiratory Muscle Dysfunction in Severe Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1116 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. F. M. Wouters
Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 26 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. F. P. Man and D. D. Sin
Effects of Corticosteroids on Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, April 1, 2005; 2(1): 78 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Vassilakopoulos, C. Roussos, and S. Zakynthinos
The immune response to resistive breathing
Eur. Respir. J., December 1, 2004; 24(6): 1033 - 1043.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the European Respiratory Society.