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Medical complications of lung transplantation

Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA, USA

CORRESPONDENCE: R.M. Kotloff, 838 West Gates, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA. Fax: 1 2156140869. E-mail: kotloff@mail.med.upenn.edu

Keywords: immunosuppressive agents, lung transplantation, lymphoproliferative disorders, pneumonia

Received: April 16, 2003
Accepted April 23, 2003

This work was supported by the Craig and Elaine Dobbin Pulmonary Research Fund of the University of Pennsylvania Medical Center, PA, USA.

Abstract

Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. Nonetheless, the post-transplant course is often marked by complications that threaten both the quality and duration of the recipient's life.

Many of the medical complications that arise are the direct consequence of the need to administer potent immunosuppressive agents, with their attendant risks of infection, malignancy and drug toxicity.

This article will review the major medical complications, excluding allograft rejection, which may be encountered in the lung transplant recipient. Familiarity with, and vigilance for, these problems should facilitate earlier recognition, more expeditious intervention and more favourable outcomes.

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